Wednesday, October 17, 2012

Ellen Goldbaum-Buffalo - Obese Boys Have Up to 50% Less Testosterone

While I have known for a long time that higher levels of fat storage equates to lower testosterone levels, I had no idea the numbers were so alarming in growing boys. The problem is that fat cells create estrogen and have estrogen receptors, so the more fat storage there is, the more estrogen is in the body. The more estrogen there is in the male body, the lower the levels of testosterone produced.

In developing boys - not to mention adult men - this has all kinds of negative effects, including enlarged breasts (and increased risk of breast cancer), reduced muscle mass, depression, impotence, and possible infertility. The fat storage combined with the reduced muscle mass can eventually lead to diabetes.

We have to stop this trend of obesity in our children, both boys and girls (who experience earlier menarche when overweight). It starts with parents and the choices they make around food and family entertainment. But it also involves city and neighborhood planning (more parks and green spaces), returning recess and P.E to schools, making healthier foods more affordable, and reshaping our cultural beliefs around food. The future does not look good - and I don't see anyone really devoting resources to the problem.

The full article is available for free online at the Clinical Endocrinology site.

Full Citation:
Mogri, M, Dhindsa, S, Quattrin,T, Ghanim, H, and Dandona, P. (2012, Sept). Testosterone concentrations in young pubertal and postpubertal obese males. Clinical Endocrinology, Vol. 77, Issue 5. doi: 10.1111/cen.12018

In obese boys, up to 50 percent less testosterone

Posted by Ellen Goldbaum-Buffalo on Tuesday, October 16, 2012

A 50 percent reduction in testosterone seen in obese boys is "frankly, horrendous, because these boys are potentially impotent and infertile," says Paresh Dandona of the University at Buffalo. "The message is a grim one with massive epidemiological implications." (Credit: "overweight boy" via Shutterstock)

U. BUFFALO (US) — Obese adolescent boys have up to 50 percent less total testosterone than do normal-weight boys of the same age, significantly increasing the risk for impotency as adults.

“We were surprised to observe a 50 percent reduction in testosterone in this pediatric study because these obese males were young and were not diabetic,” says Paresh Dandona, professor of medicine and chief of the division of endocrinology, diabetes, and metabolism at the University at Buffalo.

“The implications of our findings are, frankly, horrendous because these boys are potentially impotent and infertile. The message is a grim one with massive epidemiological implications.”

Published online in the journal Clinical Endocrinology, the small study included boys between the ages of 14 and 20—25 boys who were obese and 25 who were lean—and was controlled for age and level of sexual maturity. Concentrations of total and free testosterone and estradiol, an estrogen hormone, were measured in morning fasting blood samples.

The researchers say the results now need to be confirmed with a larger number of subjects.

“These findings demonstrate that the effect of obesity is powerful, even in the young, and that lifestyle and nutritional intake starting in childhood have major repercussions throughout all stages of life,” Dandona says.

In addition to the reproductive consequences, the absence or low levels of testosterone that were found also will increase the tendency toward abdominal fat and reduced muscle, Dandona says, leading to insulin resistance, which contributes to diabetes.

“The good news is that we know that testosterone levels do return to normal in obese adult males who undergo gastric bypass surgery,” says Dandona. “It’s possible that levels also will return to normal through weight loss as a result of lifestyle change, although this needs to be confirmed by larger studies.”

The same authors reported in 2004 the presence of low testosterone levels, known as hypogonadism, in obese, type 2 diabetic adult males and confirmed it in 2010 in more than 2,000 obese men, both diabetic and nondiabetic. They now intend to study whether or not weight loss accomplished either through lifestyle changes or through pharmacological intervention will restore testosterone levels in obese teen males.

The research was funded by the National Institutes of Health.

Source: University at Buffalo

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