Hmmmm . . . my father was 40 when I was born. I certainly got the ADHD thing. In my 20s, I was suicidal more than once. And according to my girlfriend, I am on the autistic spectrum a wee bit. Thanks dad!

This comes via Dr. Jeremy Dean at PsychBlog.

Higher Risk of Mental Illness for Those With Older Fathers

Massive study finds children with older dads much more likely to have autism, ADHD and bipolar disorder.
A new study has found that the children of older fathers have a much greater risk of serious mental illness.

The findings come from a huge number of people: everyone born in Sweden between 1973 and 2001 (D’Onofrio et al., 2014).

The researchers included over 2.5 million people, representing almost 90% of the population.

They found associations between older fathers and psychiatric conditions such as bipolar disorder, schizophrenia, autism and ADHD.

When they compared fathers who were 24-years-old with those who were 45-years old, they found that children of the older fathers were:

• 25 times more likely to have bipolar disorder,
• 13 times more likely to have ADHD,
• 3.5 times more likely to have autism,
• 2.5 times more likely to have suicidal behaviour.

The findings remained after they controlled for birth order, education and a host of other variables.

Brian D’Onofrio, the study’s lead author, expressed surprise at these numbers:

“We were shocked by the findings. The specific associations with paternal age were much, much larger than in previous studies.”

Faulty sperm

The authors suggest that the explanation for the association is that, while women are born with all their eggs, men continue to produce sperm, which degrades in quality over their lifetime.

People are exposed to all kinds of environmental toxins which could cause this kind of genetic mutation.

Molecular genetic studies have indeed found just this degradation in the quality of men’s sperm with age.

D’Onofrio concludes:

“While the findings do not indicate that every child born to an older father will have these problems, they add to a growing body of research indicating that advancing paternal age is associated with increased risk for serious problems. As such, the entire body of research can help to inform individuals in their personal and medical decision-making.”

With the average age at which men have children increasing in many countries, these findings could have important implications for both public policy and for individual decisions about when to procreate.

Image credit: Nisha A

Dr Jeremy Dean is a psychologist and the author of PsyBlog. His latest book is "Making Habits, Breaking Habits: How to Make Changes That Stick". You can follow PsyBlog on Facebook, Twitter and Google+.

Fathers Pass Obesity to Their Offspring (and Their Offspring)

Here is yet another reason for men to stay fit and healthy (besides reducing the risks of cancer, heart disease, diabetes, arthritis, and cognitive diseases) - the sperm of obese men pass on obesity genes to their children and grandchildren. If you won't or can't commit to fitness for yourself, do it for your children and grandchildren.

Dad's sperm passes obesity on

THE UNIVERSITY OF ADELAIDE
TUESDAY, 16 JULY 2013

The sperm of an obese father can increase the risk of the next two generations being obese, even if they're eating healthily.

New research from the University of Adelaide shows that the sperm of obese fathers could increase the risk of both their children and their grandchildren to inherit obesity.

In laboratory studies, researchers from the University's Robinson Institute have found that molecular signals in the sperm of obese fathers can lead to obesity and diabetes-like symptoms in two generations of offspring, even though the offspring are eating healthily.

The results of the research are published online in The FASEB Journal.

"A father's diet changes the molecular makeup of the sperm. With obese fathers, the changes in their sperm - in their microRNA molecules - might program the embryo for obesity or metabolic disease later in life," says the lead author of the paper, Dr Tod Fullston, who is an NHMRC Peter Doherty Fellow with the University's Robinson Institute, based in Dr Michelle Lane's Gamete and Embryo Biology Group.

"For female offspring, there is an increased risk of becoming overweight or obese. What we've also found is that there is an increased chance of both male and female offspring developing metabolic disease similar to type 2 diabetes.

"This is the first report of both male and female offspring inheriting a metabolic disease due to their father's obesity," he says.

The study also extended into the second generation of progeny, which showed signs of similar metabolic disorders, including obesity, although it was not as severe as the first generation.

Dr Fullston says even if the obese father does not show any signs of diabetes, metabolic disease similar to diabetes was being seen in two generations of their descendants.

"It's been known for some time that the health of a mother before, during and after pregnancy can impact on her child's health, but the father's health during this period is often overlooked," Dr Fullston says.

"If our laboratory studies are translatable to humans, this could be a new and as yet unexplored intervention window into the epidemic of childhood obesity.

"A focus on the mother's health is extremely important, but we're seeing that the father's health is also important for conception. It's possible that by showing additional attention to diet and exercise in the father, this could have a positive impact on his future children and grandchildren."

~ Editor's Note: Original news release can be found here.