Showing posts with label science. Show all posts
Showing posts with label science. Show all posts

Wednesday, August 20, 2014

The Science of Fatherhood (NPR)

This is an excellent NPR show on the science of becoming a father, and how current science has ignored or overlooked the important role of fathers.

This originally on The Daily Circuit from Minnesota Public Radio.

The science of fatherhood

The Daily Circuit · Aug 4, 2014


A picture taken April 21, 2006 shows Berlin, Germany resident Nicolas W. changing his 8-month-old daughter at home. JOHN MACDOUGALL/AFP/Getty Images

Listen: Story audio

39min 13sec

Guests
  • Dr Eli J Finkel: Professor of psychology and of management and organizations at Northwestern University
  • Paul Raeburn: Author of "Do Fathers Matter?" chief media critic at the Knight Science Journalism Tracker and blogger at About Fathers for Psychology Today
Parenting is hard work - we've always known that. There are major biological and life changes that occur when you welcome a baby into your home.

Social scientists, however, have been taking a new look at the experience of parenthood. In an article Dr Eli J Finkel in The New York Times, he said the biological changes that a man faces when he becomes a father have long been overlooked:
Although many parents happily take to their new role, millions every year respond with despair. According to a 2010 article in the Journal of the American Medical Association, among new parents -- three to six months postpartum -- 42 percent of mothers and 26 percent of fathers exhibit signs of clinical depression. In a longitudinal study reported earlier this year in the journal Pediatrics, men on average experienced significant increases in depressive symptomatology across the first five years of fatherhood (if and only if they lived with their child). Indeed, in the years after becoming a parent, both men and women experience significant reductions in their overall level of satisfaction with their lives, according to a 2008 paper in The Economic Journal.
Author Paul Raeburn says that beyond the initial transition of becoming a father, science frequently omits the role a father plays in a child's life - be it the role of a sperm donor, a bread winner, a primary caretaker or a relationship that doesn't fit into one category.

Finkel and Raeburn join The Daily Circuit to discuss how becoming a father impacts a man, and what role a father plays in a child's life.

Tuesday, April 15, 2014

Alex Berg - Bisexual Culture Is No 'Fiction'

From Huffington Post, this article and podcast examines the basis of the recent New York Times Magazine article,  The Scientific Quest to Prove Bisexuality Exists, by Benoit Denizet-Lewis.

I used to identify as bisexual, but not any more. It's another way to limit sexuality to a binary perspective. The new terms being used among those whose sexuality is more fluid than what a binary view allows, are pansexuality, or omnisexuality.

For now, at least, accepting bisexuality as a legitimate experience is a step in the correct direction.

Bisexual Culture Is No 'Fiction'

Alex Berg
Posted: 03/29/2014


In 'The Scientific Quest to Prove Bisexuality Exists,' the New York Times profiled scientific studies working to prove, once and for all, that bisexuality has a factual basis. Do bisexuals still need science to prove their sexuality is real?
Hosted by: Alex Berg
Guests:
  • Anna Pulley (Oakland, CA) Bisexual Writer and Editor
  • Ellyn Ruthstrom (Boston, MA) President of the Bisexual Resource Center
  • Dr. Herukhuti (Brooklyn , NY) Clinical Sociologist; Founder, Center for Culture, Sexuality and Spirituality
Bisexuals are "slutty." They're "men in denial about their homosexuality." Most of us are closet cases. We're "not a legitimate sexual orientation," in the eyes of 15 percent of heterosexual people. We're undermined by the "mysterious" female sexuality. We're "something you simply do," devoid of any parallel to gay culture. Sometimes, we're even "en vogue" because, you know, bisexuality is "the new black."

At least this is what the mainstream media would have you believe about us.

Last week, the New York Times Magazine featured a story by Benoit Denizet-Lewis called 'The Scientific Quest to Prove Bisexuality Exists.' The story profiled the research of the American Institute of Bisexuality, which is responsible for funding much of the scientific research around our orientation. Though the piece didn't overtly question the very existence of bisexuality itself (the New York Times already did that in 2005), it focused largely on experiments that measure pupil dilation and genital arousal in search of concrete evidence of male bisexuality. Coupled with personal stories from mostly white, bisexual cis gender people (people whose gender identity matches the sex they were assigned at birth), the research presented by Denizet-Lewis served as a reminder of the ease in which bisexual lived experiences are reduced to the offensive -- and untrue -- platitudes listed above.

Yet, while The New York Times story was imperfect for its failure to present diverse bisexual identities, a response to the piece on Slate titled 'Is Bisexual Identity a Useful Fiction?' posited whether bisexuality is more than "something you simply do" in part because "it's nearly impossible to imagine a developed bisexual culture at this point in time," according to writer Mark Joseph Stern. Stern, for his part, ultimately affirms the existence of bisexuality in men and women, but condemns the modern bisexual movement for failing culturally "...to articulate a coherent platform beyond its initial goals of recognition."

Even if these writers concede -- with hesitation of course -- that us bisexuals exist, now we do so without a cultural identity?

This might as well be the same as questioning our very existence -- it certainly translates into real life experiences that do. At it's best, it's when I'm viewed as little more than sexual meat by couples propositioning me on OkCupid, or when I'm accused of being too afraid to come out as gay. At its worst, it's precious media space devoted to how I'm perceived as "dirty," instead of exploring why 45 percent of bisexual women have contemplated or attempted suicide, why we're twice as likely to have an eating disorder compared to our lesbian counterparts and why, compared with straight women and lesbians, we have the highest rates of alcohol abuse instead.

But, I don't have to look to Slate or any other online magazine to know that when I tell people I identify as bisexual, it holds less cultural currency than when I say I'm simply "queer." Given that the term has been recently reclaimed from its pejorative roots, the political undertones are more obvious. Remove the word "bisexual" from my vocabulary, and I'm instantly more accepted in the lesbian scene; considered more dateable, and trustworthy, even. So, when in October, bisexual writer and editor Anna Pulley gave some compelling reasons in Salon why we ought to consider putting "the word to bed," it was hard to look away.

After all, "bisexual" is marked by strong negative connotations that perhaps a new term would present a re-birth for those of us with fluid identities. "I think people's attitudes toward bisexuals comprise the bigger obstacle to acceptance....We're Girls Gone Wild or giving you HIV or closet-cases taking advantage of straight privilege or stealing your boyfriend. These are hard stereotypes to fight because they're so pervasive and culturally ingrained, even among bisexuals ourselves," Pulley wrote me in an email last year. Then, the term is criticized within the queer community for being too binary. Pulley wrote in an email that "If you're involved with a person who's genderqueer, trans, or intersex, for instance, "bisexual" doesn't really cut it."

Given that "bisexual" triggers the world's-worst-dirty sex taboo, I wonder: Has this connotation, perpetuated by places like the New York Times and Slate, become so unshakeable that it's time to replace the term?

Absolutely not.

Bisexuality should, for once and all, be publicly understood under activist Robyn Ochs' definition: "I call myself bisexual because I acknowledge that I have in myself the potential to be attracted -- romantically and/or sexually -- to people of more than one sex and/or gender, not necessarily at the same time, not necessarily in the same way, and not necessarily to the same degree." While this definition itself encompasses all the identities of the LGBTQ community, in Slate, Stern wonders if its one unto itself: "Is bisexuality even an identity, in the way that homosexuality is?"

My bisexual identity is one that is defined by proudly challenging assumptions about sexuality altogether. Outsiders frequently judge my sexuality based on the gender of the person I'm with; in coming out to them as bisexual, through my capacity to love, I immediately challenge their notion of what makes a person LGBT. Faith Cheltenham, president of BiNet USA, put it this way in a phone call this week, "People think one thing about bi people and the reality is different. That's what we talk about when we use bi-culture, how people see us being different than who we are." Equally as profound is the word's rich cultural and political legacy. Just look to last year's bisexual White House summit, which helped inspire Bisexual Health Awareness Month, and the many publications, musicians, manifestos and organizations dedicated to documenting the experiences of bisexual people. If these don't constitute a "coherent platform," what does?

Perhaps most proudly, bisexual culture represents intersectionality at its core. We are cis gender and trans people alike, among all of the other identities we intersect as 50 percent of the LGBT community. Cheltenham wrote me in an email last year that for her, "Bisexuality is not who I am, it is a component of my identity. As a black woman I have other aspects of my identity that will consistently affect my life. As a black American I am more likely to have poor health outcomes. As a woman I am more likely to be affected by sexism." So, when Stern insisted in Slate that it's time for the bisexual "movement to stop substantiating its own existence and start trying to give that existence the cultural substance it craves," it made me wish I could. In fact, I'd be more than happy to stop -- as soon as the media stops looking to scientific studies to prove we exist.

Correction: An earlier version of this blog stated that no people of color were interviewed for the New York Times piece. One person of color was quoted in the piece and and several were featured in the slideshow that accompanied the piece.

Follow Alex Berg on Twitter: www.twitter.com/AlexfromPhilly

Monday, March 10, 2014

I Can Has Cheezburger? Protein Cancer Risk Overblown

If you read the health section of your local newspaper or favorite online news aggregater last week, you no doubt saw the frightening headlines about eating meat being as bad as smoking, or how high-protein diets are now linked to cancer. Here are a few of them:
* Why High-Protein Diets May Be Linked To Cancer Risk
Forbes
* Too much protein as bad as smoking
Independent Online
* High-protein diet in middle age can lead to early death
eMaxHealth
* Are burgers as bad as cigarettes? Unravelling the truth about diet and disease
Telegraph.co.uk (blog)
The research involving humans is so badly conducted that it cannot be seen as representative of even a correlation, let alone causation. The mouse portion of the study is a little more interesting, but it's still not capable of showing cause and effect.

Fortunately, New Scientist has a short but sweet debunking of all those scare-tactic headlines. And National Geographic looks at the real issue, according to other research, which is blood levels of
insulin-like growth factor-1 (IGF-1).

May or may not be bad for you <i>(Image: Lauri Patterson/Getty)</i>

I can has cheezburger? Protein cancer risk overblown

18 March 2014 by Catherine de Lange

Are you middle-aged and partial to cheeseburgers? If so, you may be concerned by a study suggesting you have a much greater risk of dying from cancer than your peers who favour a less protein-rich diet. But not all researchers agree with the study's findings.

Morgan Levine at the University of Southern California in Los Angeles and her colleagues analysed a dietary survey of more than 6300 people in the US aged over 50. Those aged 50-65 at the time of the survey and who had a high-protein diet – one where protein supplied a fifth of calories – were 75 per cent more likely to have died over the next 18 years than peers who only got 10 per cent of their calories from protein.

The high-protein eaters had a cancer death rate four times that of their low-protein peers. Statistical analyses showed that the findings only held for animal protein diets – in other words, protein from meat and dairy rather than beans and pulses.

In a follow-up study in mice, the team also found that animals fed a low-protein diet had a lower incidence of cancer than those on a high-protein diet. The low-protein mice that did develop the disease had slower-growing tumours.


Lots of leaps


But Tim Key, a Cancer Research UK epidemiologist based at the University of Oxford, says the dietary survey is too small to provide any robust conclusions.

Catherine Collins, chief dietician at St George's Hospital, London, doesn't dispute the results in mice, but says the authors make a lot of leaps when trying to apply the findings to humans. What's more, the conclusions are based on a single survey of what people reported eating in the preceding 24 hours. "As a dietician that's worrying," she says. "There are so many errors with the data collection. It implies people's diet doesn't change over 18 years."

Study co-author Valter Longo, also at the University of Southern California, counters that the participants said that the 24 hour period was representative of their diet. "Most people don't change their diet very often," he says.

Different health organisations recommend consuming different amounts of protein. Longo says that people in middle age should try to eat at the lower end of these recommendations.

Collins isn't convinced. "We don't need to do anything different, and nor should we be worried [on the strength of this study]," she says.

Journal reference: Cell Metabolism, DOI: 10.1016/j.cmet.2014.02.006
Here is the National Geographic article about IGF-1 and the health risks of having too high of levels of this growth factor (a molecule created by the metabolizing of human growth hormone).

Behind the News: Why a High-Protein Diet in Middle Age May Increase Risk of Death

Levels of a growth-related molecule in the blood may be key.


Eating a high-protein diet during middle age may be as harmful as smoking, a scientist says.  PHOTOGRAPH BY ANDREW SCRIVANI, THE NEW YORK TIMES/REDUX

Stephen S. Hall
for National Geographic
Published March 8, 2014

On March 4, scientists reported that people who ate a diet rich in protein during their middle-aged years (ages 50-65) were four times more likely to die from cancer than those who ate a low-protein diet, and had a 75 percent increase in overall mortality.

Valter Longo of the University of Southern California, who led the study, likened the risk of a high-protein diet to that of smoking. The key to these startling findings—underreported in many media accounts—is the role of a molecule called insulin-like growth factor-1 (IGF-1).

This same molecule was the prime player in a highly publicized study published three years ago by Longo, along with Jaime Guevara-Aguirre of the Institute of Endocrinology, Metabolism and Reproduction in Quito, Ecuador, and their colleagues, that looked at patients in a remote area of southern Ecuador. The subjects of the study had a rare mutation that interfered with the normal functioning of IGF-1, blocking the body's normal growth pathway. As a result, adults with the disease (known as Laron syndrome) rarely grew beyond 3 1/2 feet tall.

But the scientists observed an unusually beneficial side effect of the disease: The "Larons" did not get cancer, they claimed, and did not get diabetes, even though they were often obese. (Read "On Beyond 100" in National Geographic magazine.)

For the recent study, published in the journal Cell Metabolism, the scientists analyzed data from the Center for Disease Control and Prevention's National Health and Nutrition Examination Survey (NHANES).

In an unexpected twist, the researchers also reported evidence that after age 65, a high-protein diet seemed to have the opposite effect: It protected against mortality.

In other words, a low-protein diet during middle age appears to be protective, but the same low-protein diet in older adults has deleterious effects.

To explore these puzzling results and the role of IGF-1, National Geographic spoke with Longo earlier this week.

For a number of years you've been studying a population in Ecuador with a growth disorder, and in 2011 you reported the relative absence of cancer and diabetes mortality in people with Laron syndrome. How does this new report tie in to that earlier research?

The Laron study was a continuation of our work that we started 20 years earlier. When we put it all together, the obvious thing was, in both in mice and humans, when they eat [a low-protein diet], we predicted that they would have low levels of IGF-1. So I started bugging everybody in the world that had any databases. It turned out that here at USC, downstairs from our lab, we had some people who had been studying NHANES for years. It was a perfect database to look at, because it was nationally representative; it's done by the CDC, and the sample and the measurements are considered to be very reliable.

There are several surprising claims in this new study, but let's talk about perhaps the biggest: A high-protein diet during middle age was associated with a much greater risk of dying of any cause, especially cancer, than a low-protein diet. In fact, you liken the mortality risk of the high-protein diet to that of smoking. How would you explain this association?

The more protein you eat—and this is very clearly shown by clinical work by others—the more IGF-1 activity you have. And we see the same in mice. There was a paper that came out in the same issue of Cell Metabolism, looking at all kinds of combinations of micronutrients, and in fact the best combination for longevity was low-protein, high carbs.

And just to be clear: When you say high-protein or medium-protein diet versus low protein, what exactly do you mean?

High protein means 20 percent or more of the calories is coming from protein; moderate is 10 to 20 percent; low is less than 10. We looked at animal-based and plant-based proteins.

One of the other surprises in the study is what you refer to as a "dramatic switch"—a point when a low-protein diet seems to stop being protective and starts having negative effects. How did you identify that shift, at what age does it occur, and why do you think it happens?

So when I first sat down with the epidemiologist, the analysis was done for the whole survey, from ages 50 on up. And we saw nothing. But we were seeing in mice that if you starve a young mouse or a middle-aged mouse, it does very well. But we started seeing that when we starved old mice in the same way, they were struggling. That's when I started thinking, "Hmm, I think that there are two major phases, if not more."

I went back to the epidemiologist and said, "Can you reanalyze the data and break it down into two groups? [Up to 65 years old, and after 65.] And sure enough, she came back and said to me, "Valter, it's incredible." Now we know why we didn't see it before. [In the original analysis] the effects in the old were offsetting the effects in the middle-aged.

You also conducted complementary studies of high-protein and low-protein diets in mice and yeast. Those studies suggested a role for IGF-1. Can you explain your working hypothesis about the possible role of IGF-1 in cancer, and in mortality in general?

We know that in either animals or humans, if the diet is low in protein, the level of IGF-1 goes down—or way down, depending how severely you restrict protein. If you look at humans, it's a pretty large change [in IGF-1 levels] between the high-protein group and the lowest-protein group, with the moderate-protein group in between.

So then how does it lead to cancer? Well, that was basically our paper three years ago on the Larons, which showed that if you take the blood from the Larons [which essentially has no IGF-1] and you expose human cells to it, and then you try to damage those cells to make them precancer cells, the absence of IGF-1 has a protective effect in two ways. First, as we have known for years from yeast, the lack of IGF-1 protects DNA from damage in the first place. Second, the lower IGF-1 now makes the mammalian cell more likely to go into what is called "programmed cell death," or apoptosis.

And the cell dying in that instance is a good thing?

Yes—because it's a cell that's about to become a cancer cell. So there's a dual protective effect. You try to prevent DNA damage from happening in the first place, but when the damage does happen, the [precancerous] cell is much more likely to die.

We showed this very clearly in this new study, where a cancer [in mice] progresses more slowly on the low-protein diet.

This new paper suggests that animal proteins, as in red meat, have a different effect on this biochemical pathway than plant proteins, as in vegetables. At the biochemical level, why would cells see a difference between animal proteins and plant proteins?

When we did the mouse studies, we did see a trend for decreasing IGF-1 with soy protein versus animal protein. We are doing more studies now, looking at different protein sources and IGF-1 levels. We suspect that the amino acid profile of plant proteins is going to control IGF-1 differently, but we need to test that more carefully.

Just to make sure the proper caveats are introduced here: This study finds an association between diet and mortality, but doesn't prove that a high-protein diet in middle age causes an increased risk of dying. And one of the limitations with the NHANES study is that it is based on a single, one-time recall of a person's diet over a 24-hour period, and then you're associating mortality up to 18 years later from that single dietary report.

Well, there's not many things you can do that are not going to have limitations. I think this needs to be viewed in the context of a number of other studies done, including the Laron study.

Frank Hu at Harvard looked at high animal proteins and fats in diets and low carbs, and even if he didn't break it down into age segments, he still saw that people eating high animal food diets and low carbs were the ones with the highest overall mortality risk, the highest cancer risk, the highest cardiovascular risk.

And certainly if you look at long-lived populations around the world, this is really consistent with that. So whether it's the California centenarians, the Okinawans, the southern Italians—the common denominator seems to be a low-protein, high-plant-food-based diet.

Every experimental result points to the next experiment. What's the next step here?

We're doing a clinical trial that we started a year ago, and in that clinical trial we're basically saying to people, "Don't change what you do in terms of diet." But we do ask them to switch once a month for five days to a diet that mimics fasting. We want to see if this periodic exposure to these more extreme diets can actually reprogram the system so the IGF-1 pathway is switched to a more beneficial mode, similar to what you would see in somebody having the perfect diet.

Sunday, October 20, 2013

Ed Yong - Sexism and Harassment in the Science-Writing World


Ed Yong (photo below) blogs at National Geographic's Phenomena: Not Exactly Rocket Science blog here he does a weekly column of cool science-related articles from around the interwebs (I've got your missing links right here" - this week's is I've got your missing links right here (19 October 2013).


Before I continue, I want to mention that on the sidebar of his blog, Yong has this:

My wife, who makes it all possible  

I share this because Yong's personality and commitment to his wife is relevant to his comments on and coverage of a recent series of disturbing events in science journalism. This lends Yong more weight in his refutation of the behaviors described below.

A very well-known science writer and blogger, the Blogs Editor at Scientific American, and co-founder of ScienceOnline.com - Bora Zivkovic - was accused by first one and then several science writers - all female - of sexual harassment.

The pattern is pretty distinct in each of their stories
[Bora] contacted her, showed interest in her work, met with her, and then proceeded to steer the conversation straight towards sex (such as repeatedly telling her he was a "very sexual person.")
This is all so effing disturbing as a man - I work with women who go through this is much less public ways. Often, as is the case with Kathleen Raven, this kind of harassment devolves into rape.

I am so proud of these women for speaking out and revealing the culture of control and power in which they work. And I applaud Ed Yong for featuring this story on his blog this weekend.

Ladybits have issued a call for submissions on the power of harassment.

So with that, here is the opening to this week's "missing links" column.

Sexism and harassment in the science-writing world

It’s been a bit of a week in the science-writing world. First, Scientific American blogger Danielle Lee wrote about an editor who asked her to write for free and called her a whore when she turned him down. SciAm took down the post with inconsistent explanations, prompting a fierce online response. Maryn McKenna sums up the story and I’d really recommend this post by Kate Clancy. The post is back up; the editor, fired.

In the wake of that, writer Monica Byrne accused Bora Zivkovic, a leading figure in the science blogging community, of harassment. He apologised, but concurrently other women stepped forward, including science writers Hannah Waters and Kathleen Raven. The women are brave; their accounts, devastating. Raven’s is the most gut-wrenching thing I have read in recent memory. Trigger warnings apply.

The event has also prompted a lot of good pieces on gender and power issues in the science community. This is a non-exhaustive list, but: many good pieces on Ladybits; Melanie Tannenbaum on the psychology of impact vs. intent; Alice Bell on the nature of the sci-blogging community; Laura Helmuth with sage advice for people seeking mentorship (and those who can provide it), and more; Martin Robbins on keep-it-quiet-ism.

The whole thing also led to the heartbreaking #ripplesofdoubt hashtag as many people shared their stories of how pervasive harassment and sexism affects them. See Hope Jahren’s piece.

I’m pushing this to the foreground because it’s more important than any of the stuff below. We need to open our eyes. We need to ensure that our colleagues don’t have to go through this, and certainly not alone. We need to speak up about it because doing so will create a culture where people can speak up about it, where they can stand up and be supported. Not this. [emphasis added]

More coverage here, here, here.

Wednesday, October 2, 2013

Shelly Fan - The Fat-Fueled Brain: Unnatural or Advantageous?


The current method of doing a ketogenic diet is not like the popular version in the press, a misrepresentation based on Dr. Atkins' original keto diet in the early 1970s. At that time, the medical establishment thought he was crazy for advocating a diet based primarily on protein (mostly from meat) and fat. The popular image was the steak and bacon diet, with a side of whole cream or a stick of butter.

But he persisted and the evidence and research began to accumulate. As this evidence mounted, Atkins responded to some of the criticisms of his diet by changing the emphasis from high-fat red meat to chicken, fish, and turkey. He also reduced the recommended amounts of saturated fats in the diet.

As of now, many experts suggest that saturated fats should be around 10-15% of all calories from fat, with the remained 85-90% divided between monounsaturated fats (almonds, olive oil) and polyunsaturated fats (omega-3, -6, and -9 from fish, flax seed, pumpkin seeds, walnuts, and other nuts).

By the early 2000s, low-carb diets were the fad, and like all fads, it faded away and Americans continued to get fatter, unhealthier, and more resigned to living that way. But in many circles, various versions of the keto diet live on - as the Paleo Diet of Loren Cordain, Ph.D., or as a general low-carb lifestyle adopted by many fitness enthusiasts and athletes.

The reason we can do a low-carb or even a no carb diet is because, of the four macronutrients (water, protein, fats, and carbohydrates), only three are essential to human life. Can you guess the one that isn't?

You got it - carbohydrates are not an essential macronutrient for human survival.

I have been eating a low-carb diet for the better part of 10 years. In the last 3-5 yrs it has become very low-carb. My energy is better, more level throughout the day, my brain is sharp, my mood is more steady, and despite everything you might read, it has not hurt my workouts. Granted, if I planned to ride my bike for 2-3 hours, I would probably ingest a couple of cans of pumpkin the night before so that I have some reserves of carbohydrate and pop a gell if I feel myself approaching a bonk. But I don't do that. I can ride hard for an hour on an empty stomach (well, on 12 grams of BCAAs) and feel great.

It's not really that hard to do this kind of a diet. Many days, my only carbohydrate source is 2 cups of mixed berries (mostly blueberries, raspberries, blackberries, and black cherries) with my cottage cheese for breakfast. Late morning or noonish I might have a couple of chicken sausages (120 calories each, 15 grams of protein, 5 grams of fat), a couple of sticks of lite string cheese (50 calories each, 7 grams of protein, 2.5 grams of fat) and a handful of walnuts or almonds. A few hours later it might be 6-8 oz. of deli chicken or turkey between two thick slices of part-skim mozzarella, or a chicken breast with some spinach or broccoli. Finally, I often have 2-4 squares of 90% dark chocolate with almond butter or sunflower seed butter. [During the day I might eat 2-5 additional tablespoons of almond butter, sunflower seed butter, or some other type of nut butter, though usually not peanut butter so much anymore.]

My version of this diet is what works for my body (trial and error). I generally eat more protein than the typical keto diet, which can be up to 75-90% fat. And I supplement a lot of my fats with fish oil (8-10 grams a day), pumpkin oil (4-5 grams a day), conjugated linoleic acid (CLA, 4-5 grams a day), and omega-3/6/9 (4-5 grams a day) - for a whopping total of 20-25 grams a day.

Anyway, here is an article from Scientific American Mind looking at the current research on ketogenic diets and the many health benefits we can reap from ditching carbohydrates.

The fat-fueled brain: Unnatural or advantageous?


By Shelly Fan | October 1, 2013

Disclaimer: First things first. Please note that I am in no way endorsing nutritional ketosis as a supplement to, or a replacement for medication. As you’ll see below, data exploring the potential neuroprotective effects of ketosis are still scarce, and we don’t yet know the side effects of a long-term ketogenic diet. This post talks about the SCIENCE behind ketosis, and is not meant in any way as medical advice.


It’s not bacon; it’s therapy! Source: Renée S. Suen on Flickr.

The ketogenic diet is a nutritionist’s nightmare. High in saturated fat and VERY low in carbohydrates, “keto” is adopted by a growing population to paradoxically promote weight loss and mental well-being. Drinking coffee with butter? Eating a block of cream cheese? Little to no fruit? To the uninitiated, keto defies all common sense, inviting skeptics to wave it off as an unnatural “bacon-and-steak” fad diet.

Yet versions of the ketogenic diet have been used to successfully treat drug-resistant epilepsy in children since the 1920s – potentially even back in the biblical ages. Emerging evidence from animal models and clinical trials suggest keto may be therapeutically used in many other neurological disorders, including head ache, neurodegenerative diseases, sleep disorders, bipolar disorder, autism and brain cancer. With no apparent side effects.

Sound too good to be true? I feel ya! Where are these neuroprotective effects coming from? What’s going on in the brain on a ketogenic diet?


Ketosis in a nutshell


In essence, a ketogenic diet mimics starvation, allowing the body to go into a metabolic state called ketosis (key-tow-sis). Normally, human bodies are sugar-driven machines: ingested carbohydrates are broken down into glucose, which is mainly transported and used as energy or stored as glycogen in liver and muscle tissue. When deprived of dietary carbohydrates (usually below 50g/day), the liver becomes the sole provider of glucose to feed your hungry organs – especially the brain, a particularly greedy entity accounting for ~20% of total energy expenditure. The brain cannot DIRECTLY use fat for energy. Once liver glycogen is depleted, without a backup energy source, humanity would’ve long disappeared in the eons of evolution.

The backup is ketone bodies that the liver derives primarily from fatty acids in your diet or body fat. These ketones – β-hydroxybutyrate (BHB), acetoacetate and acetone – are released into the bloodstream, taken up by the brain and other organs, shuttled into the “energy factory” mitochondria and used up as fuel. Excess BHB and acetoacetate are excreted from urine, while acetone, due to its volatile nature, is breathed out (hence the characteristically sweet “keto breath”). Meanwhile, blood glucose remains physiologically normal due to glucose derived from certain amino acids and the breakdown of fatty acids – voila, low blood sugar avoided!


Carbohydrate restriction induces the pancreas to "tell" fat cells to release fatty acids, which get taken up by the liver and converted into ketones and released into blood. Once taken up by the brain, ketones enter the TCA cycle to generate energy. Source: Shelly Fan. (click to see large)


Brain on ketones: Energetics, Oxidation and Inflammation


So the brain is happily deriving energy from ketones – sure, but why would this be protective against such a variety of brain diseases?

One answer may be energy. Despite their superficial differences, many neurological diseases share one major problem – deficient energy production. During metabolic stress, ketones serve as an alternative energy source to maintain normal brain cell metabolism. In fact, BHB (a major ketone) may be an even more efficient fuel than glucose, providing more energy per unit oxygen used. A ketogenic diet also increases the number of mitochondria, so called “energy factories” in brain cells. A recent study found enhanced expression of genes encoding for mitochondrial enzymes and energy metabolism in the hippocampus, a part of the brain important for learning and memory. Hippocampal cells often degenerate in age-related brain diseases, leading to cognitive dysfunction and memory loss. With increased energy reserve, neurons may be able to ward off disease stressors that would usually exhaust and kill the cell.

A ketogenic diet may also DIRECTLY inhibit a major source of neuronal stress, by –well- acting like a blueberry. Reactive oxygen species are unfortunate byproducts of cellular metabolism. Unlike the gas Oxygen, these “oxidants” have a single electron that makes them highly reactive, bombarding into proteins and membranes and wrecking their structure. Increased oxidants are a hallmark of aging, stroke and neurodegeneration.

Ketones directly inhibit the production of these violent molecules, and enhance their breakdown through increasing the activity of glutathione peroxidase, a part of our innate anti-oxidant system. The low intake of carbohydrates also directly reduces glucose oxidation (something called “glycolysis”). Using a glucose-like non-metabolized analogue, one study found that neurons activate stress proteins to lower oxidant levels and stabilize mitochondria.

Due to its high fat nature, keto increases poly-unsaturated fatty acids (PUFAs, such as DHA and EPA, both sold over-the-counter as “brain healthy” supplements), which in turn reduces oxidant production and inflammation. Inflammatory stress is another “root of all evil”, which PUFAs target by inhibiting the expression of genes encoding for pro-inflammatory factors.


Neurons on Ketones: Dampen that enthusiasm!


Excited neurons transmit signals, process information and form the basis of a functioning brain. OVER-excited neurons tend to die.

The brain teeters on a balance between excitation and inhibition through two main neurotransmitters, the excitatory glutamate and the inhibitory GABA. Tilt the scale towards glutamate, which occurs in stroke, seizures and neurodegeneration, and you get excitotoxicity. In other words, hyper-activity is toxic.

Back in the 1930s, researchers found that direct injection of various ketone bodies into rabbits prevented chemically-induced seizures through inhibiting glutamate release, but the precise mechanism was unclear. A recent study in hippocampal neurons showed that ketones directly inhibited the neuron’s ability to “load up” on glutamate – that is, the transmitter can’t be packaged into vesicles and released – and thus decreased excitatory transmission. In a model of epilepsy that used a chemical similar to glutamate to induce damage, the diet protected mice against cell death in the hippocampus by inhibiting pro-death signaling molecules. On the other end of the excitation-inhibition balance, ketones increase GABA in the synapses (where neurotransmitters are released) of rats and in the brains of some (but not all) epileptic humans subjects. This increase in inhibition may confer both anti-seizure effects and neuroprotection, though data is still scant.

Then there are some fringe hypotheses. The acidity of ketones may decrease the pH of certain brain microdomains, which might be the mechanism of keto’s positive effect on Type II Bipolar disorder (lots of mays and mights, I know). As keto affects the whole body, global changes due to calorie restriction and regulation of the satiety hormone Leptin are bound to alter brain function, and play a circumstantial role.


Neuroprotection? Show me the evidence!


All these molecular changes suggest that a ketogenic diet is protective against brain injury. But is there any REAL evidence?

A study with 23 elderly with mild cognitive impairment showed that a ketogenic diet improved verbal memory performance after 6 weeks compared to a standard high carbohydrate diet. In a double-blind, placebo-controlled study, 152 patients with mild- to moderate Alzheimer’s disease were given either a ketogenic agent or a placebo, while maintaining a normal diet. 90 days later, those receiving the drug showed marked cognitive improvement compared to placebo, which was correlated with the level of ketones in the blood.

In a pilot study in 7 patients with Parkinson’s disease, 5 were able to stick to the diet for 28 days and showed marked reduction in their physical symptoms. In an animal model of Amytrophic Lateral Sclerosis (ALS), a ketogenic diet also led to delayed motor neuron death and histological and functional improvements, although it did not increase life span; clinical trials are on the way.

Remarkably, a long-term ketogenic diet does not seem to be associated with significant side effects, although constipation, dehydration and electrolyte and micronutrient deficiencies are common complaints. More serious complications include increased chance of kidney stones, gallbladder problems and bone fractures, especially in children. Menstrual irregularities often occur in women, with potential impact on fertlity. Although ketoacidosis – acidification of the blood due to pathological levels of ketones – was historically proposed as a side effect, nutritional ketosis simply cannot achieve the level of ketones required to induce this life-threatening state. Nevertheless, there are no studies directly monitoring the side effects of ketosis yet, hence it’s too early to conclude that the diet is completely safe for everyone.


Brain [hearts] Bacon

While promising, large-scale placebo-controlled clinical trials in patients with neurological disorders are still lacking. The existing data needs to be interpreted carefully to avoid generating false hope or encourage patients to “ditch drugs for diet”. Nevertheless, the possibility that we can reduce symptoms of untreatable neurological disorders through modifying dietary composition is quite incredible; that a ketogenic diet may benefit physical and cognitive performance in healthy individuals is an even more tantalizing idea.

As the science behind this age-old dietary therapy gradually comes to light, social issues such as low adherence and public prejudice will need to be resolved. In the meantime, to those neuroscientists interested in studying keto: pass the bacon and I VOLUNTEER!

Final note: Before I let you go, I’d like to stress again that keto is NOT something to try out without talking to your doctor first, nor is it a replacement for pharmaceuticals. There’s simply not enough evidence, on either its effectiveness or side effects. Nevertheless, it’s a cool area of research to keep an eye on!

Monday, December 3, 2012

Steven Ross Pomeroy - The Key to Science (and Life) Is Being Wrong

When do you learn the most about life, who you are, relationships? I'm guessing it's not when you are right about something, or sure of yourself. Most of can only learn through making mistakes or being wrong. Yet we avoid being wrong like the plague. When we can acknowledge that we are wrong about something and be open to other ideas or perspectives, that is when we grow as men, as human beings.

The Key to Science (and Life) Is Being Wrong

November 13, 2012


 

In 1964, the occasionally enigmatic but always energetic physicist, Dr. Richard Feynman gave a lecture at Cornell University to a packed hall of eager, young scholars. Feynman’s demeanor was crisp and purposeful that day, a style reinforced by his sharp appearance. The professor’s hair was neat and tidy, and he was keenly attired in a trim, tailored suit.

His right hand grasping a piece of chalk, his left had nestled in his coat pocket, Feynman started to speak. “I’m going to discuss how we would look for a new law,” he said in his unvarnished Queens accent, referring to his work as a theoretical physicist.

Feynman walked over to the chalkboard and began to write. His oration continued, almost in a manner synced with his scribbling. “First we guess it… Then we compute the consequences of the guess to see what it would imply. And then we compare those computation results… directly to observation to see if it works.”

Feynman paused, removed his left hand from his coat pocket, and strode back over to the lectern to briefly peruse some notes. He then launched right back into his sermon.

“If it disagrees with experiment, it’s wrong,” he asserted, craning his neck forward and adroitly pointing his left hand at the chalkboard to accentuate the point. “In that simple statement, is the key to science.”

“It doesn’t make any difference how beautiful your guess is,” Feynman proclaimed, gesticulating in wide, circular, somewhat flamboyant motions. “It doesn’t make any difference how smart you are, who made the guess, or what his name is. If it disagrees with experiment, it’s wrong. That’s all there is to it.”

Feynman was absolutely right.

A good scientist must be willing to be wrong. Such an inclination is liberating, for it allows him or her to investigate potential answers — however unlikely they may be — to the difficult questions inspired by this vast, wondrous universe. Not only that, a willingness to be wrong frees a scientist to pursue any avenue opened by evidence, even if that evidence doesn’t support his or her original hunch.

“The hard but just rule is that if the ideas don’t work, you must throw them away,” The great science communicator Carl Sagan wrote. “Don’t waste neurons on what doesn’t work. Devote those neurons to new ideas that better explain the data.”

 

Sagan’s candid advice was perfectly followed in 1998, when two highly competitive groups of scientists from Harvard and Berkeley were racing to find the rate at which the universe’s expansion was decelerating. It was a high stakes contest, for a Nobel Prize was thought to be on the line.

But to both groups’ astonishment, the data ended up pointing in precisely the opposite direction. The scientists found that the universe’s expansion was not slowing down; it was speeding up! “I was, quite frankly, denying [it] was happening,” Harvard’s Brian Schmidt reportedly said. But because Schmidt and his colleagues overcame their disappointment and were willing to be wrong, the world learned something entirely new about the cosmos.

For the Berkeley and Harvard astrophysicists, recognizing their wrongness was easy, as the data irrefutably pointed in a completely different direction. But it’s not always that simple. Sometimes data can be inconclusive, leaving wiggle room for the researcher to draw a range of conclusions. Unfortunately, this occasionally leads to misconduct, especially for the scientists who are more interested in dogmatically pursuing pet theories instead of proof. They might tweak little bits of data in order to achieve statistical significance in the ubiquitous P-value test or they might ignore certain details that conflict with their hypothesis.

This is, of course, ethically wrong, but human nature often compels us to err in order to guard our ingrained beliefs. While scientists are oft considered to be marble men and women, the truth is, they never stop being human.

In order to recognize wrongness, scientists must maintain some level of detachment from their cherished theories and be open to the ideas of others in their respective fields. Richard Dawkins described a terrific example of this in his book, The God Delusion:
“I have previously told the story of a respected elder statesman of the Zoology Department at Oxford when I was an undergraduate. For years he had passionately believed, and taught, that the Golgi Apparatus (a microscopic feature of the interior of cells) was not real… Every Monday afternoon it was the custom for the whole department to listen to a research talk by a visiting lecturer. One Monday, the visitor was an American cell biologist who presented completely convincing evidence that the Golgi Apparatus was real. At the end of the lecture, the old man strode to the front of the hall, shook the American by the hand and said – with passion – ‘My dear fellow, I wish to thank you. I have been wrong these fifteen years.’”
In the past year, we’ve been treated to two uplifting examples of that sort of modesty. Last year, University of California physics professor Richard Muller changed his skeptical stance on climate change when his own “BEST” study produced data that conflicted with his preconceived notions. He now admits that climate change is caused by human activity. In another noteworthy example, Dr. Robert Spitzer, the psychiatrist who, in a 2001 paper, touted that gays could be “cured,” reversed his position and apologized for his “fatally flawed, study.”

“I believe I owe the gay community an apology,” Spitzer wrote in a letter.

Wrongness is something we all secretly or openly dread. According to self-described “Wrongologist” Kathryn Schulz, in the abstract, we all understand that we’re fallible, but on the personal level, we leave little to no room for being wrong.

But Schulz believes that we should view this situation in a slightly different light. Realizing you’re wrong is what’s devastating, but being wrong often feels pretty good. As a matter of fact, it often feels identical to being right.

Like Wile E. Coyote chasing Road Runner off a cliff in those old Warner Brothers cartoons, we only start to fall when we come to the realization that we, along with our incorrect notions, have no solid ground to stand on. But the simple fact of the matter is that we had already run off the end of the precipice a long time ago! Thus, it’s best to admit that we’re wrong and get the fall over with so we can land (hopefully not too harshly), dust ourselves off, and get back on our feet.

——
Images: Richard Feynman: Wikimedia Commons/Public Domain, Universe Ladder: NASA/JPL-Caltech


Steven Ross Pomeroy 
About the Author: Steven Ross Pomeroy is the assistant editor for Real Clear Science, a science news aggregator. He regularly contributes to RCS’ Newton Blog. As a writer, Steven believes that his greatest assets are his insatiable curiosity and his ceaseless love for learning. Follow on Twitter @SteRoPo.
The views expressed are those of the author and are not necessarily those of Scientific American.

Wednesday, April 25, 2012

Dogs Decoded - The Remarkable Bond Between Humans and Their Dogs


Man's best friend. . . . In country music and popular cliche, nothing comes between a man and his dog, not even (or especially) his woman. This 2010 NOVA episode, reposted at Documentary Heaven, looks at the long and complicated history between human and dogs.




Dogs Decoded

Broadcast (2010) "Dogs Decoded" reveals the science behind the remarkable bond between humans and their dogs and investigates new discoveries in genetics that are illuminating the origin of dogs—with surprising implications for the evolution of human culture. Other research is proving what dog lovers have suspected all along: Dogs have an uncanny ability to read and respond to human emotions. Humans, in turn, respond to dogs with the same hormone responsible for bonding mothers to their babies. How did this incredible relationship between humans and dogs come to be? And how can dogs, so closely related to fearsome wild wolves, behave so differently?

Dogs have been domesticated for longer than any other animal on the planet, and humans have developed a unique relationship with these furry friends. We treat our pets like a part of the family, and feel that they can understand us in a way other animals can't. Now, new research is revealing what dog lovers have suspected all along: Dogs have an uncanny ability to read and respond to human emotions. Humans, in turn, respond to dogs with the same hormone responsible for bonding mothers to their babies. How did this incredible relationship between humans and dogs come to be? And how can dogs, so closely related to fearsome wild wolves, behave so differently? It's all in the genes.

Dogs Decoded investigates new discoveries in genetics that are illuminating the origin of dog - with big implications for the evolution of human culture as well. In Siberia, the mystery of dogs' domestication is being repeated--in foxes. A fifty-year-old breeding program is creating an entirely new kind of creature, a tame fox with some surprising similarities to Man's Best Friend.

Friday, March 9, 2012

The Science of Gender And Science, Pinker Vs. Spelke - A Debate

This Edge-sponsored debate with Steven Pinker and Elizabeth Spelke occurred in 2005, not long after former Secretary of the Treasury (under Clinton), former Harvard president (2001-2005), and former Director of the National Economic Council (under Obama) Lawrence Summers made some ill-considered comments (which lead to his forced resignation from Harvard) on sex differences between men and women and how they may relate to the careers of women in science.

This is 7 years old, and it's long, but the same arguments are still being made on each side of the debate, so it's definitely worth reading (or listening to - there is a link below).
Pinker Vs. Spelke

A Debate [5.16.05]




...on the research on mind, brain, and behavior that may be relevant to gender disparities in the sciences, including the studies of bias, discrimination and innate and acquired difference between the sexes.

Harvard University • Mind/Brain/Behavior Initiative

The Mind Brain and Behavior Inter-Faculty Initiative (MBB), under the leadership of Co-Directors Marc D. Hauser and Elizabeth Spelke, is a university-wide community that studies the structure, function, evolution, development, and pathology of the nervous system, in relation to decision-making and behavior.

Introduction

On April 22, 2005, Harvard University's Mind/Brain/Behavior Initiative (MBB) held a defining debate on the public discussion that began on January 16th with the public comments by Lawrence Summers, president of Harvard, on sex differences between men and women and how they may relate to the careers of women in science. The debate at MBB, "The Gender of Gender and Science" was "on the research on mind, brain, and behavior that may be relevant to gender disparities in the sciences, including the studies of bias, discrimination and innate and acquired difference between the sexes".

It's interesting to note that since the controversy surrounding Summers' remarks began, there has been an astonishing absence of discussion of the relevant science...you won't find it in the hundreds and hundreds of articles in major newspapers; nor will find it in the Harvard faculty meetings where the president of the leading University in America was indicted for presenting controversial ideas.

Scientists debate continually, and reality is the check. They may have egos as large as those possessed by the iconic figures of the academic humanities, but they handle their hubris in a very different way. They can be moved by arguments, because they work in an empirical world of facts, a world based on reality. There are no fixed, unalterable positions. They are both the creators and the critics of their shared enterprise. Ideas come from them and they also criticize one another's ideas.

Through the process of creativity and criticism and debates, they decide which ideas get weeded out and which become part of the consensus that leads to the next level of discovery.

But unlike just about anything else said about Summers' remarks, the debate, "The Science of Gender and Science", between Harvard psychology professors Steven Pinker and Elizabeth Spelke, focused on the relevant scientific literature. It was both interesting on facts but differing in interpretation.

Both presented scientific evidence with the realization and understanding that there was nothing obvious about how the data was to be interpreted. Their sharp scientific debate informed rather than detracted. And it showed how a leading University can still fulfill its role of providing a forum for free and open discussion on controversial subjects in a fair-minded way. It also had the added benefit that the participants knew what they were talking about.

Who won the debate? Make up your own mind. Watch the video, listen to the audio, read the text and check out the slide presentations.

There's a lesson here: let's get it right and when we do we will adjust our attitudes. That's what science can do, and that's what Edge offers by presenting Pinker vs. Spelke to a wide public audience.
JB

STEVEN PINKER is the Johnstone Family Professor in the Department of Psychology at Harvard University. His research has won prizes from the National Academy of Sciences and the Royal Institution of Great Britain, and he is the author of six books, including The Language Instinct, How the Mind Works, Words and Rules, and The Blank Slate.
Steven Pinker's Edge Bio Page

ELIZABETH S. SPELKE is Berkman Professor of Psychology at Harvard University, where she is Co-Director of the Mind, Brain, and Behavior Initiative. A member of the National Academy of Sciences and the American Academy of Arts and Sciences, she is cited by Time Magazine as one of America's Best in Science and Medicine.

THE SCIENCE OF GENDER AND SCIENCE
PINKER VS. SPELKE

A DEBATE

[EDITOR'S NOTE: Pinker and Spelke each made presentations of about 40 minutes, without interruption, from each other or from the audience. They then responded to each other's presentations. By mutual agreement, Pinker made the first presentation.

This Edge presentation includes: the transcribed text; streaming audio of the full debate; 6-minute video clips from Pinker and Spelke's opening statements; a 20-minute video clip of the their closing discussion; and online versions of the speakers' slide presentations. There are two options for viewing the slides: Clicking on the links immediately below brings up the file of either Pinker or Spelke's complete slide presentation. Or, the individual slides are also included for reference as expandable thumbnails in the margin of the transcript.]

The complete video, in .avi format, is also available for download through Harvard's MBB website (click here).



Steven Pinker


(STEVEN PINKER:) Thanks, Liz, for agreeing to this exchange. It's a privilege to be engaged in a conversation with Elizabeth Spelke. We go back a long way. We have been colleagues at MIT, where I helped attract her, and at Harvard, where she helped to attract me. With the rest of my field, I have enormous admiration for Elizabeth's brilliant contributions to our understanding of the origins of cognition. But we do find ourselves with different perspectives on a recent issue.

For those of you who just arrived from Mars, there has been a certain amount of discussion here at Harvard on a particular datum, namely the under-representation of women among tenure-track faculty in elite universities in physical science, math, and engineering. Here are some recent numbers:

As with many issues in psychology, there are three broad ways to explain this phenomenon. One can imagine an extreme "nature" position: that males but not females have the talents and temperaments necessary for science. Needless to say, only a madman could take that view. The extreme nature position has no serious proponents.

There is an extreme "nurture" position: that males and females are biologically indistinguishable, and all relevant sex differences are products of socialization and bias.

Then there are various intermediate positions: that the difference is explainable by some combination of biological differences in average temperaments and talents interacting with socialization and bias.

Liz has embraced the extreme nurture position. There is an irony here, because in most discussions in cognitive science she and I are put in the same camp, namely the "innatists," when it comes to explaining the mind. But in this case Liz has said that there is "not a shred of evidence" for the biological factor, that "the evidence against there being an advantage for males in intrinsic aptitude is so overwhelming that it is hard for me to see how one can make a case at this point on the other side," and that "it seems to me as conclusive as any finding I know of in science."

Well we certainly aren't seeing the stereotypical gender difference in confidence here! Now, I'm a controversial guy. I've taken many controversial positions over the years, and, as a member of Homo sapiens, I think I am right on all of them. But I don't think that in any of them I would say there is "not a shred of evidence" for the other side, even if I think that the evidence favors one side. I would not say that the other side "can't even make a case" for their position, even if I think that their case is not as good as the one I favor. And as for saying that a position is "as conclusive as any finding in science" — well, we're talking about social science here! This statement would imply that the extreme nurture position on gender differences is more conclusive than, say the evidence that the sun is at the center of the solar system, for the laws of thermodynamics, for the theory of evolution, for plate tectonics, and so on.

These are extreme statements — especially in light of the fact that an enormous amount of research, summarized in these and many other literature reviews, in fact points to a very different conclusion. I'll quote from one of them, a book called Sex Differences in Cognitive Ability by Diane Halpern. She is a respected psychologist, recently elected as president of the American Psychological Association, and someone with no theoretical axe to grind. She does not subscribe to any particular theory, and has been a critic, for example, of evolutionary psychology. And here what she wrote in the preface to her book:
"At the time I started writing this book it seemed clear to me that any between sex differences in thinking abilities were due to socialization practices, artifacts, and mistakes in the research. After reviewing a pile of journal articles that stood several feet high, and numerous books and book chapters that dwarfed the stack of journal articles, I changed my mind. The literature on sex differences in cognitive abilities is filled with inconsistent findings, contradictory theories, and emotional claims that are unsupported by the research. Yet despite all the noise in the data, clear and consistent messages could be heard. There are real and in some cases sizable sex differences with respect to some cognitive abilities. Socialization practices are undoubtedly important, but there is also good evidence that biological sex differences play a role in establishing and maintaining cognitive sex differences, a conclusion I wasn't prepared to make when I began reviewing the relevant literature."
This captures my assessment perfectly.

Again for the benefit of the Martians in this room: This isn't just any old issue in empirical psychology. There are obvious political colorings to it, and I want to begin with a confession of my own politics. I am a feminist. I believe that women have been oppressed, discriminated against, and harassed for thousands of years. I believe that the two waves of the feminist movement in the 20th century are among the proudest achievements of our species, and I am proud to have lived through one of them, including the effort to increase the representation of women in the sciences.

But it is crucial to distinguish the moral proposition that people should not be discriminated against on account of their sex — which I take to be the core of feminism — and the empirical claim that males and females are biologically indistinguishable. They are not the same thing. Indeed, distinguishing them is essential to protecting the core of feminism. Anyone who takes an honest interest in science has to be prepared for the facts on a given issue to come out either way. And that makes it essential that we not hold the ideals of feminism hostage to the latest findings from the lab or field. Otherwise, if the findings come out as showing a sex difference, one would either have to say, "I guess sex discrimination wasn't so bad after all," or else furiously suppress or distort the findings so as to preserve the ideal. The truth cannot be sexist. Whatever the facts turn out to be, they should not be taken to compromise the core of feminism.

Why study sex differences? Believe me, being the Bobby Riggs of cognitive science is not my idea of a good time. So should I care about them, especially since they are not the focus of my own research?

First, differences between the sexes are part of the human condition. We all have a mother and a father. Most of us are attracted to members of the opposite sex, and the rest of us notice the difference from those who do. And we can't help but notice the sex of our children, friends, and our colleagues, in every aspect of life.

Also, the topic of possible sex differences is of great scientific interest. Sex is a fundamental problem in biology, and sexual reproduction and sex differences go back a billion years. There's an interesting theory, which I won't have time to explain, which predicts that there should be an overall equal investment of organisms in their sons and daughters; neither sex is predicted to be superior or inferior across the board. There is also an elegant theory, namely Bob Trivers' theory of differential parental investment, which makes highly specific predictions about when you should expect sex differences and what they should look like.

The nature and source of sex differences are also of practical importance. Most of us agree that there are aspects of the world, including gender disparities, that we want to change. But if we want to change the world we must first understand it, and that includes understanding the sources of sex differences.

Let's get back to the datum to be explained. In many ways this is an exotic phenomenon. It involves biologically unprepared talents and temperaments: evolution certainly did not shape any part of the mind to do the work of a professor of mechanical engineering at MIT, for example. The datum has nothing to do with basic cognitive processes, or with those we use in our everyday lives, in school, or even in most college courses, where indeed there are few sex differences.

Also, we are talking about extremes of achievement. Most women are not qualified to be math professors at Harvard because most men aren't qualified to be math professors at Harvard. These are extremes in the population.

And we're talking about a subset of fields. Women are no under-represented to nearly the same extent in all academic fields, and certainly not in all prestigious professions.

Finally, we are talking about a statistical effect. This is such a crucial point that I have to discuss it in some detail.

Women are nowhere near absent even from the field in which they are most under-represented. The explanations for sex differences must be statistical as well. And here is a touchstone for the entire discussion:

These are two Gaussian or normal distributions; two bell curves. The X axis stands for any ability you want to measure. The Y axis stands for the proportion of people having that ability. The overlapping curves are what you get whenever you compare the sexes on any measure in which they differ. In this example, if we say that this is the male curve and this is the female curve, the means may be different, but at any particular ability level there are always representatives of both genders.

So right away a number of public statements that have been made last couple of months can be seen as red herrings, and should never have been made by anyone who understands the nature of statistical distributions. This includes the accusation that President Summers implied that "50% of the brightest minds in America do not have the right aptitude for science," that "women just can't cut it," and so on. These statements are statistically illiterate, and have nothing to do with the phenomena we are discussing.

There are some important corollaries of having two overlapping normal distributions. One is that a normal distribution falls off according to the negative exponential of the square of the distance from the mean. That means that even when there is only a small difference in the means of two distributions, the more extreme a score, the greater the disparity there will be in the two kinds of individuals having such a score. That is, the ratios get more extreme as you go farther out along the tail. If we hold a magnifying glass to the tail of the distribution, we see that even though the distributions overlap in the bulk of the curves, when you get out to the extremes the difference between the two curves gets larger and larger.

For example, it's obvious that distributions of height for men and women overlap: it's not the case that all men are taller than all women. But while at five foot ten there are thirty men for every woman, at six feet there are two thousand men for every woman. Now, sex differences in cognition tend not to be so extreme, but the statistical phenomenon is the same.

A second important corollary is that tail ratios are affected by differences in variance. And biologists since Darwin have noted that for many traits and many species, males are the more variable gender. So even in cases where the mean for women and the mean for men are the same, the fact that men are more variable implies that the proportion of men would be higher at one tail, and also higher at the other. As it's sometimes summarized: more prodigies, more idiots.

With these statistical points in mind, let me begin the substance of my presentation by connecting the political issue with the scientific one. Economists who study patterns of discrimination have long argued (generally to no avail) that there is a crucial conceptual difference between difference and discrimination. A departure from a 50-50 sex ratio in any profession does not, by itself, imply that we are seeing discrimination, unless the interests and aptitudes of the two groups are equated. Let me illustrate the point with an example, involving myself.

I work in a scientific field — the study of language acquisition in children — that is in fact dominated by women. Seventy-five percent of the members the main professional association are female, as are a majority of the keynote speakers at our main conference. I'm here to tell you that it's not because men like me have been discriminated against. I decided to study language development, as opposed to, say, mechanical engineering, for many reasons. The goal of designing a better automobile transmission does not turn me on as much as the goal of figuring out how kids acquire language. And I don't think I'd be as good at designing a transmission as I am in studying child language.

Now, all we need to do to explain sex differences without invoking the discrimination or invidious sexist comparisons is to suppose that whatever traits I have that predispose me to choose (say) child language over (say) mechanical engineering are not exactly equally distributed statistically among men and women. For those of you out there — of either gender — who also are not mechanical engineers, you should understand what I'm talking about.

Okay, so what are the similarities and differences between the sexes? There certainly are many similarities. Men and women show no differences in general intelligence or g — on average, they are exactly the same, right on the money. Also, when it comes to the basic categories of cognition — how we negotiate the world and live our lives; our concept of objects, of numbers, of people, of living things, and so on — there are no differences.

Indeed, in cases where there are differences, there are as many instances in which women do slightly better than men as ones in which men do slightly better than women. For example, men are better at throwing, but women are more dexterous. Men are better at mentally rotating shapes; women are better at visual memory. Men are better at mathematical problem-solving; women are better at mathematical calculation. And so on.

But there are at least six differences that are relevant to the datum we have been discussing. The literature on these differences is so enormous that I can only touch on a fraction of it. I'll restrict my discussion to a few examples in which there are enormous data sets, or there are meta-analyses that boil down a literature.

The first difference, long noted by economists studying employment practices, is that men and women differ in what they state are their priorities in life. To sum it up: men, on average, are more likely to chase status at the expense of their families; women give a more balanced weighting. Once again: Think statistics! The finding is not that women value family and don't value status. It is not that men value status and don't value family. Nor does the finding imply that every last woman has the asymmetry that women show on average or that every last man has the asymmetry that men show on average. But in large data sets, on average, an asymmetry what you find.

Just one example. In a famous long-term study of mathematically precocious youth, 1,975 youngsters were selected in 7th grade for being in the top 1% of ability in mathematics, and then followed up for more than two decades. These men and women are certainly equally talented. And if anyone has ever been encouraged in math and science, these kids were. Both genders: they are equal in their levels of achievement, and they report being equally satisfied with the course of their lives. Nonetheless there are statistical differences in what they say is important to them. There are some things in life that the females rated higher than males, such as the ability to have a part-time career for a limited time in one's life; living close to parents and relatives; having a meaningful spiritual life; and having strong friendships. And there are some things in life that the males rated higher than the females. They include having lots of money; inventing or creating something; having a full-time career; and being successful in one's line of work. It's worth noting that studies of highly successful people find that single-mindedness and competitiveness are recurring traits in geniuses (of both sexes).

Here is one other figure from this data set. As you might expect, this sample has a lot of people who like to work Herculean hours. Many people in this group say they would like to work 50, 60, even 70 hours a week. But there are also slight differences. At each one of these high numbers of hours there are slightly more men than women who want to work that much. That is, more men than women don't care about whether they have a life.

Second, interest in people versus things and abstract rule systems. There is a staggering amount of data on this trait, because there is an entire field that studies people's vocational interests. I bet most of the people in this room have taken a vocational interest test at some point in their lives. And this field has documented that there are consistent differences in the kinds of activities that appeal to men and women in their ideal jobs. I'll just discuss one of them: the desire to work with people versus things. There is an enormous average difference between women and men in this dimension, about one standard deviation.

And this difference in interests will tend to cause people to gravitate in slightly different directions in their choice of career. The occupation that fits best with the "people" end of the continuum is "director of a community services organization." The occupations that fit best with the "things" end are physicist, chemist, mathematician, computer programmer, and biologist.

We see this consequence not only in the choice of whether to go into science, but also in the choice which branch of science the two sexes tend to go into. Needless to say, from 1970 to 2002 there was a huge increase in the percentage of university degrees awarded to women. But the percentage still differs dramatically across fields. Among the Ph.Ds awarded in 2001, for example, in education 65% of the doctorates went to women; in the social sciences, 54%; in the life sciences, 47%; in the physical sciences, 26%; in engineering, 17%. This is completely predictable from the difference in interests between people and living things, on the one hand, and inanimate objects, on the other. And the pattern is pretty much the same in 1980 and 2001, despite the change in absolute numbers.

Third, risk. Men are by far the more reckless sex. In a large meta-analysis involving 150 studies and 100,000 participants, in 14 out of 16 categories of risk-taking, men were over-represented. The two sexes were equally represented in the other two categories, one of which was smoking, for obvious reasons. And two of the largest sex differences were in "intellectual risk taking" and "participation in a risky experiment." We see this sex difference in everyday life, in particular, in the following category: the Darwin Awards, "commemorating those individuals who ensure the long-term survival of our species by removing themselves from the gene pool in a sublimely idiotic fashion." Virtually all — perhaps all — of the winners are men.

Fourth, three-dimensional mental transformations: the ability to determine whether the drawings in each of these pairs the same 3-dimensional shape. Again I'll appeal to a meta-analysis, this one containing 286 data sets and 100,000 subjects. The authors conclude, "we have specified a number of tests that show highly significant sex differences that are stable across age, at least after puberty, and have not decreased in recent years." Now, as I mentioned, for some kinds of spatial ability, the advantage goes to women, but in "mental rotation,"spatial perception," and "spatial visualization" the advantage goes to men.

Now, does this have any relevance to scientific achievement? We don't know for sure, but there's some reason to think that it does. In psychometric studies, three-dimensional spatial visualization is correlated with mathematical problem-solving. And mental manipulation of objects in three dimensions figures prominently in the memoirs and introspections of most creative physicists and chemists, including Faraday, Maxwell, Tesla, Kéekulé, and Lawrence, all of whom claim to have hit upon their discoveries by dynamic visual imagery and only later set them down in equations. A typical introspection is the following: "The cyclical entities which seem to serve as elements in my thought are certain signs and more or less clear images which can be voluntarily reproduced and combined. This combinatory play seems to be the essential feature in productive thought before there is any connection with logical construction in words or other kinds of signs." The quote comes from this fairly well-known physicist.

Fifth, mathematical reasoning. Girls and women get better school grades in mathematics and pretty much everything else these days. And women are better at mathematical calculation. But consistently, men score better on mathematical word problems and on tests of mathematical reasoning, at least statistically. Again, here is a meta analysis, with 254 data sets and 3 million subjects. It shows no significant difference in childhood; this is a difference that emerges around puberty, like many secondary sexual characteristics. But there are sizable differences in adolescence and adulthood, especially in high-end samples. Here is an example of the average SAT mathematical scores, showing a 40-point difference in favor of men that's pretty much consistent from 1972 to 1997. In the Study of Mathematically Precocious Youth (in which 7th graders were given the SAT, which of course ordinarily is administered only to older, college-bound kids), the ratio of those scoring over 700 is 2.8 to 1 male to female. (Admittedly, and interestingly, that's down from 25 years ago, when the ratio was 13-to1, and perhaps we can discuss some of the reasons.) At the 760 cutoff, the ratio nowadays is 7 males to 1 female.

Now why is there a discrepancy with grades? Do SATs and other tests of mathematical reasoning aptitude underpredict grades, or do grades overpredict high-end aptitude? At the Radical Forum Liz was completely explicit in which side she takes, saying that "the tests are no good," unquote. But if the tests are really so useless, why does every major graduate program in science still use them — including the very departments at Harvard and MIT in which Liz and I have selected our own graduate students?

I think the reason is that school grades are affected by homework and by the ability to solve the kinds of problems that have already been presented in lecture and textbooks. Whereas the aptitude tests are designed to test the application of mathematical knowledge to unfamiliar problems. And this, of course, is closer to the way that math is used in actually doing math and science.

Indeed, contrary to Liz, and the popular opinion of many intellectuals, the tests are surprisingly good. There is an enormous amount of data on the predictive power of the SAT. For example, people in science careers overwhelmingly scored in 90th percentile in the SAT or GRE math test. And the tests predict earnings, occupational choice, doctoral degrees, the prestige of one's degree, the probability of having a tenure-track position, and the number of patents. Moreover this predictive power is the same for men and for women. As for why there is that underprediction of grades — a slight under-prediction, one-tenth of a standard deviation — the Educational Testing Service did a study on that phenomenon, and were able to explain the mystery by a combination of the choice of major, which differs between the sexes, and the greater conscientiousness of women.

Finally there's a sex difference in variability. It's crucial here to look at the right samples. Estimates of variance depend highly on the tails of the distribution, which by definition contain smaller numbers of people. Since people at the tails of the distribution in many surveys are likely to be weeded out for various reasons, it's important to have large representative samples from national populations. In this regard the gold standard is the Science paper by Novell and Hedges, which reported six large stratified probability samples. They found that in 35 out of 37 tests, including all of the tests in math, space, and science, the male variance was greater than the female variance.

One other data set meeting the gold standard is displayed in this graph, showing the entire population of Scotland, who all took an intelligence test in a single year. The X axis represents IQ, where the mean is 100, and the Y axis represents the proportion of men versus women. As you can see these are extremely orderly data. In the middle part of the range, females predominate; at both extremes, males slightly predominate. Needless to say, there is a large percentage of women at both ends of the scale — but there is also large sex difference.

Now the fact that these six gender differences exist does not mean that they are innate. This of course is a much more difficult issue to resolve. A necessary preamble to this discussion is that nature and nurture are not alternatives; it is possible that the explanation for a given sex difference involves some of each. The only issue is whether the contribution of biology is greater than zero. I think that there are ten kinds of evidence that the contribution of biology is greater than zero, though of course it is nowhere near 100 percent.

First, there are many biological mechanisms by which a sex difference could occur. There are large differences between males and females in levels of sex hormones, especially prenatally, in the first six months of life, and in adolescence. There are receptors for hormones all over the brain, including the cerebral cortex. There are many small differences in men's and women's brains, including the overall size of the brain (even correcting for body size), the density of cortical neurons, the degree of cortical asymmetry, the size of hypothalamic nuclei, and several others.

Second, many of the major sex differences — certainly some of them, maybe all of them, are universal. The idea that there are cultures out there somewhere in which everything is the reverse of here turns out to be an academic legend. In his survey of the anthropological literature called Human Universals, the anthropologist Donald Brown points out that in all cultures men and women are seen as having different natures; that there is a greater involvement of women in direct child care; more competitiveness in various measures for men than for women; and a greater spatial range traveled by men compared to by women.

In personality, we have a cross-national survey (if not a true cross-cultural one) in Feingold's meta-analysis, which noted that gender differences in personality are consistent across ages, years of data collection, educational levels, and nations. When it comes to spatial manipulation and mathematical reasoning, we have fewer relevant data, and we honestly don't have true cross-cultural surveys, but we do have cross-national surveys. David Geary and Catherine Desoto found the expected sex difference in mental rotation in ten European countries and in Ghana, Turkey, and China. Similarly, Diane Halpern, analyzing results from ten countries, said that "the majority of the findings show amazing cross-cultural consistency when comparing males and females on cognitive tests."

Third, stability over time. Surveys of life interests and personality have shown little or no change in the two generations that have come of age since the second wave of feminism. There is also, famously, resistance to change in communities that, for various ideological reasons, were dedicated to stamping out sex differences, and found they were unable to do so. These include the Israeli kibbutz, various American Utopian communes a century ago, and contemporary androgynous academic couples.

In tests of mental rotation, the meta-analysis by Voyer et al found no change over time. In mathematical reasoning there has been a decline in the size of the difference, although it has certainly not disappeared.

Fourth, many sex differences can be seen in other mammals. It would be an amazing coincidence if these differences just happened to be replicated in the arbitrary choices made by human cultures at the dawn of time. There are large differences between males and females in many mammals in aggression, in investment in offspring, in play aggression play versus play parenting, and in the range size, which predicts a species' sex differences in spatial ability (such as in solving mazes), at least in polygynous species, which is how the human species is classified. Many primate species even show a sex difference in their interest in physical objects versus conspecifics, a difference seen their patterns of juvenile play. Among baby vervet monkeys, the males even prefer to play with trucks and the females with other kinds of toys!

Fifth, many of these differences emerge in early childhood. It is said that there is a technical term for people who believe that little boys and little girls are born indistinguishable and are molded into their natures by parental socialization. The term is "childless."

Some sex differences seem to emerge even in the first week of life. Girls respond more to sounds of distress, and girls make more eye contact than boys. And in a study that I know Liz disputes and that I hope we'll talk about, newborn boys were shown to be more interested in looking at a physical object than a face, whereas newborn girls were shown to be more interested in looking at a face than a physical object.

A bit later in development there are vast and robust differences between boys and girls, seen all over the world. Boys far more often than girls engage in rough-and-tumble play, which involves aggression, physical activity, and competition. Girls spend a lot more often in cooperative play. Girls engage much more often in play parenting. And yes, boys the world over turn anything into a vehicle or a weapon, and girls turn anything into a doll. There are sex differences in intuitive psychology, that is, how well children can read one another's minds. For instance, several large studies show that girls are better than boys in solving the "false belief task," and in interpreting the mental states of characters in stories.

Sixth, genetic boys brought up as girls. In a famous 1970s incident called the John/Joan case, one member of a pair of identical twin boys lost his penis in a botched circumcision (I was relieved to learn that this was not done by a moyl, but by a bumbling surgeon). Following advice from the leading gender expert of the time, the parents agreed to have the boy castrated, given female-specific hormones, and brought up as a girl. All this was hidden from him throughout his childhood.

When I was an undergraduate the case was taught to me as proof of how gender roles are socially acquired. But it turned out that the facts had been suppressed. When "Joan" and her family were interviewed years later, it turned out that from the youngest ages he exhibited boy-typical patterns of aggression and rough-and-tumble play, rejected girl-typical activities, and showed a greater interest in things than in people. At age 14, suffering from depression, his father finally told him the truth. He underwent further surgery, married a woman, adopted two children, and got a job in a slaughterhouse.

This is not just a unique instance. In a condition called cloacal exstrophy, genetic boys are sometimes born without normal male genitalia. When they are castrated and brought up as girls, in 25 out of 25 documented instances they have felt that they were boys trapped in girls' bodies, and showed male-specific patterns of behavior such as rough-and-tumble play.

Seventh, a lack of differential treatment by parents and teachers. These conclusions come as a shock to many people. One comes from Lytton and Romney's meta-analysis of sex-specific socialization involving 172 studies and 28,000 children, in which they looked both at parents' reports and at direct observations of how parents treat their sons and daughters — and found few or no differences among contemporary Americans. In particular, there was no difference in the categories "Encouraging Achievement" and "Encouraging Achievement in Mathematics."

There is a widespread myth that teachers (who of course are disproportionately female) are dupes who perpetuate gender inequities by failing to call on girls in class, and who otherwise having low expectations of girls' performance. In fact Jussim and Eccles, in a study of 100 teachers and 1,800 students, concluded that teachers seemed to be basing their perceptions of students on those students' actual performances and motivation.

Eighth, studies of prenatal sex hormones: the mechanism that makes boys boys and girls girls in the first place. There is evidence, admittedly squishy in parts, that differences in prenatal hormones make a difference in later thought and behavior even within a given sex. In the condition called congenital adrenal hyperplasia, girls in utero are subjected to an increased dose of androgens, which is neutralized postnatally. But when they grow up they have male-typical toy preferences — trucks and guns — compared to other girls, male-typical play patterns, more competitiveness, less cooperativeness, and male-typical occupational preferences. However, research on their spatial abilities is inconclusive, and I cannot honestly say that there are replicable demonstrations that CAH women have male-typical patterns of spatial cognition.

Similarly, variations in fetal testosterone, studied in various ways, show that fetal testosterone has a nonmonotic relationship to reduced eye contact and face perception at 12 months, to reduced vocabulary at 18 months, to reduced social skills and greater narrowness of interest at 48 months, and to enhanced mental rotation abilities in the school-age years.

Ninth, circulating sex hormones. I'm going to go over this slide pretty quickly because the literature is a bit messy. Though it's possible that all claims of the effects of hormones on cognition will turn out to be bogus, I suspect something will be salvaged from this somewhat contradictory literature. There are, in any case, many studies showing that testosterone levels in the low-normal male range are associated with better abilities in spatial manipulation. And in a variety of studies in which estrogens are compared or manipulated, there is evidence, admittedly disputed, for statistical changes in the strengths and weaknesses in women's cognition during the menstrual cycle, possibly a counterpart to the changes in men's abilities during their daily and seasonal cycles of testosterone.

My last kind of evidence: imprinted X chromosomes. In the past fifteen years an entirely separate genetic system capable of implementing sex differences has been discovered. In the phenomenon called genetic imprinting, studied by David Haig and others, a chromosome such as the X chromosome can be altered depending on whether it was passed on from one's mother or from one's father. This makes a difference in the condition called Turner syndrome, in which a child has just one X chromosome, but can get it either from her mother or her father. When she inherits an X that is specific to girls, on average she has a better vocabulary and better social skills, and is better at reading emotions, at reading body language, and at reading faces.

A remark on stereotypes, and then I'll finish.

Are these stereotypes? Yes, many of them are (although, I must add, not all of them — for example, women's superiority in spatial memory and mathematical calculation. There seems to be a widespread assumption that if a sex difference conforms to a stereotype, the difference must have been caused by the stereotype, via differential expectations for boys and for girls. But of course the causal arrow could go in either direction: stereotypes might reflect differences rather than cause them. In fact there's an enormous literature in cognitive psychology which says that people can be good intuitive statisticians when forming categories and that their prototypes for conceptual categories track the statistics of the natural world pretty well. For example, there is a stereotype that basketball players are taller on average than jockeys. But that does not mean that basketball players grow tall, and jockeys shrink, because we expect them to have certain heights! Likewise, Alice Eagly and Jussim and Eccles have shown that most of people's gender stereotypes are in fact pretty accurate. Indeed the error people make is in the direction of underpredicting sex differences.

To sum up: I think there is more than "a shred of evidence" for sex differences that are relevant to statistical gender disparities in elite hard science departments. There are reliable average difference in life priorities, in an interest in people versus things, in risk-seeking, in spatial transformations, in mathematical reasoning, and in variability in these traits. And there are ten kinds of evidence that these differences are not completely explained by socialization and bias, although they surely are in part.

A concluding remark. None of this provides grounds for ignoring the biases and barriers that do keep women out of science, as long as we keep in mind the distinction between fairness on the one hand and sameness on the other. And I will give the final word to Gloria Steinem: "there are very few jobs that actually require a penis or a vagina, and all the other jobs should be open to both sexes."



Elizabeth Spelke


(ELIZABETH SPELKE:) Thanks, especially to Steve; I'm really glad we're able to have this debate, I've been looking forward to it.

I want to start by talking about the points of agreement between Steve and me, and as he suggested, there are many. If we got away from the topic of sex and science, we'd be hard pressed to find issues that we disagree on. Here are a few of the points of agreement that are particularly relevant to the discussions of the last few months.

First, we agree that both our society in general and our university in particular will be healthiest if all opinions can be put on the table and debated on their merits. We also agree that claims concerning sex differences are empirical, they should be evaluated by evidence, and we'll all be happier and live longer if we can undertake that evaluation as dispassionately and rationally as possible. We agree that the mind is not a blank slate; in fact one of the deepest things that Steve and I agree on is that there is such a thing as human nature, and it is a fascinating and exhilarating experience to study it. And finally, I think we agree that the role of scientists in society is rather modest. Scientists find things out. The much more difficult questions of how to use that information, live our lives, and structure our societies are not questions that science can answer. Those are questions that everybody must consider.

So where do we disagree?

We disagree on the answer to the question, why in the world are women scarce as hens' teeth on Harvard's mathematics faculty and other similar institutions? In the current debate, two classes of factors have been said to account for this difference. In one class are social forces, including overt and covert discrimination and social influences that lead men and women to develop different skills and different priorities. In the other class are genetic differences that predispose men and women to have different capacities and to want different things.

In his book, The Blank Slate, and again today, Steve argued that social forces are over-rated as causes of gender differences. Intrinsic differences in aptitude are a larger factor, and intrinsic differences in motives are the biggest factor of all. Most of the examples that Steve gave concerned what he takes to be biologically based differences in motives.

My own view is different. I think the big forces causing this gap are social factors. There are no differences in overall intrinsic aptitude for science and mathematics between women and men. Notice that I am not saying the genders are indistinguishable, that men and women are alike in every way, or even that men and women have identical cognitive profiles. I'm saying that when you add up all the things that men are good at, and all the things that women are good at, there is no overall advantage for men that would put them at the top of the fields of math and science.

On the issue of motives, I think we're not in a position to know whether the different things that men and women often say they want stem only from social forces, or in part from intrinsic sex differences. I don't think we can know that now.

I want to start with the issue that's clearly the biggest source of debate between Steve and me: the issue of differences in intrinsic aptitude. This is the only issue that my own work and professional knowledge bear on. Then I will turn to the social forces, as a lay person as it were, because I think they are exerting the biggest effects. Finally, I'll consider the question of intrinsic motives, which I hope we'll come back to in our discussion.

Over the last months, we've heard three arguments that men have greater cognitive aptitude for science. The first argument is that from birth, boys are interested in objects and mechanics, and girls are interested in people and emotions. The predisposition to figure out the mechanics of the world sets boys on a path that makes them more likely to become scientists or mathematicians. The second argument assumes, as Galileo told us, that science is conducted in the language of mathematics. On the second claim, males are intrinsically better at mathematical reasoning, including spatial reasoning. The third argument is that men show greater variability than women, and as a result there are more men at the extreme upper end of the ability distribution from which scientists and mathematicians are drawn. Let me take these claims one by one.

The first claim, as Steve said, is gaining new currency from the work of Simon Baron-Cohen. It's an old idea, presented with some new language. Baron-Cohen says that males are innately predisposed to learn about objects and mechanical relationships, and this sets them on a path to becoming what he calls "systematizers." Females, on the other hand, are innately predisposed to learn about people and their emotions, and this puts them on a path to becoming "empathizers." Since systematizing is at the heart of math and science, boys are more apt to develop the knowledge and skills that lead to math and science.

To anyone as old as I am who has been following the literature on sex differences, this may seem like a surprising claim. The classic reference on the nature and development of sex differences is a book by Eleanor Maccoby and Carol Jacklin that came out in the 1970s. They reviewed evidence for all sorts of sex differences, across large numbers of studies, but they also concluded that certain ideas about differences between the genders were myths. At the top of their list of myths was the idea that males are primarily interested in objects and females are primarily interested in people. They reviewed an enormous literature, in which babies were presented with objects and people to see if they were more interested in one than the other. They concluded that there were no sex differences in these interests.

Nevertheless, this conclusion was made in the early 70s. At that time, we didn't know much about babies' understanding of objects and people, or how their understanding grows. Since Baron-Cohen's claims concern differential predispositions to learn about different kinds of things, you could argue that the claims hadn't been tested in Maccoby and Jacklin's time. What does research now show?

Let me take you on a whirlwind tour of 30 years of research in one powerpoint slide. From birth, babies perceive objects. They know where one object ends and the next one begins. They can't see objects as well as we can, but as they grow their object perception becomes richer and more differentiated.

Babies also start with rudimentary abilities to represent that an object continues to exist when it's out of view, and they hold onto those representations longer, and over more complicated kinds of changes, as they grow. Babies make basic inferences about object motion: inferences like, the force with which an object is hit determines the speed with which it moves. These inferences undergo regular developmental changes over the infancy period.

In each of these cases, there is systematic developmental change, and there's variability. Because of this variability, we can compare the abilities of male infants to females. Do we see sex differences? The research gives a clear answer to this question: We don't.

Male and female infants are equally interested in objects. Male and female infants make the same inferences about object motion, at the same time in development. They learn the same things about object mechanics at the same time.

Across large numbers of studies, occasionally a study will favor one sex over the other. For example, girls learn that the force with which something is hit influences the distance it moves a month earlier than boys do. But these differences are small and scattered. For the most part, we see high convergence across the sexes. Common paths of learning continue through the preschool years, as kids start manipulating objects to see if they can get a rectangular block into a circular hole. If you look at the rates at which boys and girls figure these things out, you don't find any differences. We see equal developmental paths.

I think this research supports an important conclusion. In discussions of sex differences, we need to ask what's common across the two sexes. One thing that's common is infants don't divide up the labor of understanding the world, with males focusing on mechanics and females focusing on emotions. Male and female infants are both interested in objects and in people, and they learn about both. The conclusions that Maccoby and Jacklin drew in the early 1970s are well supported by research since that time.

Let me turn to the second claim. People may have equal abilities to develop intuitive understanding of the physical world, but formal math and science don't build on these intuitions. Scientists use mathematics to come up with new characterizations of the world and new principles to explain its functioning. Maybe males have an edge in scientific reasoning because of their greater talent for mathematics.

As Steve said, formal mathematics is not something we have evolved to do; it's a recent accomplishment. Animals don't do formal math or science, and neither did humans back in the Pleistocene. If there is a biological basis for our mathematical reasoning abilities, it must depend on systems that evolved for other purposes, but that we've been able to harness for the new purpose of representing and manipulating numbers and geometry.

Research from the intersecting fields of cognitive neuroscience, neuropsychology, cognitive psychology, and cognitive development provide evidence for five "core systems" at the foundations of mathematical reasoning. The first is a system for representing small exact numbers of objects — the difference between one, two, and three. This system emerges in human infants at about five months of age, and it continues to be present in adults. The second is a system for discriminating large, approximate numerical magnitudes — the difference between a set of about ten things and a set of about 20 things. That system also emerges early in infancy, at four or five months, and continues to be present and functional in adults.

The third system is probably the first uniquely human foundation for numerical abilities: the system of natural number concepts that we construct as children when we learn verbal counting. That construction takes place between about the ages of two and a half and four years. The last two systems are first seen in children when they navigate. One system represents the geometry of the surrounding layout. The other system represents landmark objects.

All five systems have been studied quite extensively in large numbers of male and female infants. We can ask, are there sex differences in the development of any of these systems at the foundations of mathematical thinking? Again, the answer is no. I will show you data from just two cases.

The first is the development of natural number concepts, constructed by children between the ages of two and four. At any particular time in this period, you'll find a lot of variability. For example, between the ages of three and three and a half years, some children have only figured out the meaning of the word "one" and can only distinguish the symbolic concept one from all other numbers. Other kids have figured out the meanings of all the words in the count list up to "ten" or more, and they can use all of them in a meaningful way. Most kids are somewhere in between: they have figured out the first two symbols, or the first three, and so forth. When you compare children's performance by sex, you see no hint of a superiority of males in constructing natural number concepts.

The other example comes from studies that I think are the closest thing in preschool children to the mental rotation tests conducted with adults. In these studies, children are brought into a room of a given shape, something is hidden in a corner, and then their eyes are closed and they're spun around. They have to remember the shape of the room, open their eyes, and figure out how to rotate themselves back to the object where it was hidden. If you test a group of 4 year olds, you find they can do this task well above chance but not perfectly; there's a range of performance. When you break that performance down by gender, again there is not a hint of an advantage for boys over girls.

These findings and others support two important points. First, indeed there is a biological foundation to mathematical and scientific reasoning. We are endowed with core knowledge systems that emerge prior to any formal instruction and that serve as a basis for mathematical thinking. Second, these systems develop equally in males and females. Ten years ago, the evolutionary psychologist and sex difference researcher, David Geary, reviewed the literature that was available at that time. He concluded that there were no sex differences in "primary abilities" underlying mathematics. What we've learned in the last ten years continues to support that conclusion.

Sex differences do emerge at older ages. Because they emerge later in childhood, it's hard to tease apart their biological and social sources. But before we attempt that task, let's ask what the differences are.

I think the following is a fair statement, both of the cognitive differences that Steve described and of others. When people are presented with a complex task that can be solved through multiple different strategies, males and females sometimes differ in the strategy that they prefer.

For example, if a task can only be solved by representing the geometry of the layout, we do not see a difference between men and women. But if the task can be accomplished either by representing geometry or by representing individual landmarks, girls tend to rely on the landmarks, and boys on the geometry. To take another example, when you compare the shapes of two objects of different orientations, there are two different strategies you can use. You can attempt a holistic rotation of one of the objects into registration with the other, or you can do point-by-point featural comparisons of the two objects. Men are more likely to do the first; women are more likely to do the second.

Finally, the mathematical word problems on the SAT-M very often allow multiple solutions. Both item analyses and studies of high school students engaged in the act of solving such problems suggest that when students have the choice of solving a problem by plugging in a formula or by doing Ven diagram-like spatial reasoning, girls tend to do the first and boys tend to do the second.

Because of these differences, males and females sometimes show differing cognitive profiles on timed tests. When you have to solve problems fast, some strategies will be faster than others. Thus, females perform better at some verbal, mathematical and spatial tasks, and males perform better at other verbal, mathematical, and spatial tasks. This pattern of differing profiles is not well captured by the generalization, often bandied about in the popular press, that women are "verbal" and men are "spatial." There doesn't seem to be any more evidence for that than there was for the idea that women are people-oriented and men are object-oriented. Rather the differences are more subtle.

Does one of these two profiles foster better learning of math than the other? In particular, is the male profile better suited to high-level mathematical reasoning?

At this point, we face a question that's been much discussed in the literature on mathematics education and mathematical testing. The question is, by what yardstick can we decide whether men or women are better at math?

Some people suggest that we look at performance on the SAT-M, the quantitative portion of the Scholastic Assessment Test. But this suggestion raises a problem of circularity. The SAT test is composed of many different types of items. Some of those items are solved better by females. Some are solved better by males. The people who make the test have to decide, how many items of each type to include? Depending on how they answer that question, they can create a test that makes women look like better mathematicians, or a test that makes men look like better mathematicians. What's the right solution?

Books are devoted to this question, with much debate, but there seems to be a consensus on one point: The only way to come up with a test that's fair is to develop an independent understanding of what mathematical aptitude is and how it's distributed between men and women. But in that case, we can't use performance on the SAT to give us that understanding. We've got to get that understanding in some other way. So how are we going to get it?

A second strategy is to look at job outcomes. Maybe the people who are better at mathematics are those who pursue more mathematically intensive careers. But this strategy raises two problems. First, which mathematically intensive jobs should we choose? If we choose engineering, we will conclude that men are better at math because more men become engineers. If we choose accounting, we will think that women are better at math because more women become accountants: 57% of current accountants are women. So which job are we going to pick, to decide who has more mathematical talent?

These two examples suggest a deeper problem with job outcomes as a measure of mathematical talent. Surely you've got to be good at math to land a mathematically intensive job, but talent in mathematics is only one of the factors influencing career choice. It can't be our gold standard for mathematical ability.

So what can be? I suggest the following experiment. We should take a large number of male students and a large number of female students who have equal educational backgrounds, and present them with the kinds of tasks that real mathematicians face. We should give them new mathematical material that they have not yet mastered, and allow them to learn it over an extended period of time: the kind of time scale that real mathematicians work on. We should ask, how well do the students master this material? The good news is, this experiment is done all the time. It's called high school and college.

Here's the outcome. In high school, girls and boys now take equally many math classes, including the most advanced ones, and girls get better grades. In college, women earn almost half of the bachelor's degrees in mathematics, and men and women get equal grades. Here I respectfully disagree with one thing that Steve said: men and women get equal grades, even when you only compare people within a single institution and a single math class. Equating for classes, men and women get equal grades.

The outcome of this large-scale experiment gives us every reason to conclude that men and women have equal talent for mathematics. Here, I too would like to quote Diane Halpern. Halpern reviews much evidence for sex differences, but she concludes, "differences are not deficiencies." Men and women have equal aptitude for mathematics. Yes, there are sex differences, but they don't add up to an overall advantage for one sex over the other.

Let me turn to the third claim, that men show greater variability, either in general or in quantitative abilities in particular, and so there are more men at the upper end of the ability distribution. I can go quickly here, because Steve has already talked about the work of Camilla Benbow and Julian Stanley, focusing on mathematically precocious youth who are screened at the age of 13, put in intensive accelerated programs, and then followed up to see what they achieve in mathematics and other fields.

As Steve said, students were screened at age 13 by the SAT, and there were many more boys than girls who scored at the highest levels on the SAT-M. In the 1980s, the disparity was almost 13 to 1. It is now substantially lower, but there still are more boys among the very small subset of people from this large, talented sample who scored at the very upper end. Based on these data, Benbow and Stanley concluded that there are more boys than girls in the pool from which future mathematicians will be drawn. But notice the problem with this conclusion: It's based entirely on the SAT-M. This test, and the disparity it revealed, are in need of an explanation, a firmer yardstick for assessing and understanding gender differences in this talented population.

Fortunately, Benbow, Stanley and Lubinski have collected much more data on these mathematically talented boys and girls: not just the ones with top scores on one timed test, but rather the larger sample of girls and boys who were accelerated and followed over time. Let's look at some of the key things that they found.

First, they looked at college performance by the talented sample. They found that the males and females took equally demanding math classes and majored in math in equal numbers. More girls majored in biology and more boys in physics and engineering, but equal numbers of girls and boys majored in math. And they got equal grades. The SAT-M not only under-predicts the performance of college women in general, it also under-predicted the college performance of women in the talented sample. These women and men have been shown to be equally talented by the most meaningful measure we have: their ability to assimilate new, challenging material in demanding mathematics classes at top-flight institutions. By that measure, the study does not find any difference between highly talented girls and boys.

So, what's causing the gender imbalance on faculties of math and science? Not differences in intrinsic aptitude. Let's turn to the social factors that I think are much more important. Because I'm venturing outside my own area of work, and because time is short, I won't review all of the social factors producing differential success of men and women. I will talk about just one effect: how gender stereotypes influence the ways in which males and females are perceived.

Let me start with studies of parents' perceptions of their own children. Steve said that parents report that they treat their children equally. They treat their boys and girls alike, and they encourage them to equal extents, for they want both their sons and their daughters to succeed. This is no doubt true. But how are parents perceiving their kids?

Some studies have interviewed parents just after the birth of their child, at the point where the first question that 80% of parents ask — is it a boy or a girl? — has been answered. Parents of boys describe their babies as stronger, heartier, and bigger than parents of girls. The investigators also looked at the babies' medical records and asked whether there really were differences between the boys and girls in weight, strength, or coordination. The boys and girls were indistinguishable in these respects, but the parents' descriptions were different.

At 12 months of age, girls and boys show equal abilities to walk, crawl, or clamber. But before one study, Karen Adolph, an investigator of infants' locomotor development, asked parents to predict how well their child would do on a set of crawling tasks: Would the child be able to crawl down a sloping ramp? Parents of sons were more confident that their child would make it down the ramp than parents of daughters. When Adolph tested the infants on the ramp, there was no difference whatever between the sons and daughters, but there was a difference in the parents' predictions.

My third example, moving up in age, comes from the studies of Jackie Eccles. She asked parents of boys and girls in sixth grade, how talented do you think your child is in mathematics? Parents of sons were more likely to judge that their sons had talent than parents of daughters. A panoply of objective measures, including math grades in school, performance on standardized tests, teachers' evaluations, and children's expressed interest in math, revealed no differences between the girls and boys. Still, there was a difference in parents' perception of their child's intangible talent. Other studies have shown a similar effect for science.

There's clearly a mismatch between what parents perceive in their kids and what objective measures reveal. But is it possible that the parents are seeing something that the objective measures are missing? Maybe the boy getting B's in his math class really is a mathematical genius, and his mom or dad has sensed that. To eliminate that possibility, we need to present observers with the very same baby, or child, or Ph.D. candidate, and manipulate their belief about the person's gender. Then we can ask whether their belief influences their perception.

It's hard to do these studies, but there are examples, and I will describe a few of them. A bunch of studies take the following form: you show a group of parents, or college undergraduates, video-clips of babies that they don't know personally. For half of them you give the baby a male name, and for the other half you give the baby a female name. (Male and female babies don't look very different.) The observers watch the baby and then are asked a series of questions: What is the baby doing? What is the baby feeling? How would you rate the baby on a dimension like strong-to-weak, or more intelligent to less intelligent? There are two important findings.

First, when babies do something unambiguous, reports are not affected by the baby's gender. If the baby clearly smiles, everybody says the baby is smiling or happy. Perception of children is not pure hallucination. Second, children often do things that are ambiguous, and parents face questions whose answers aren't easily readable off their child's overt behavior. In those cases, you see some interesting gender labeling effects. For example, in one study a child on a video-clip was playing with a jack-in-the-box. It suddenly popped up, and the child was startled and jumped backward. When people were asked, what's the child feeling, those who were given a female label said, "she's afraid." But the ones given a male label said, "he's angry." Same child, same reaction, different interpretation.

In other studies, children with male names were more likely to be rated as strong, intelligent, and active; those with female names were more likely to be rated as little, soft, and so forth.

I think these perceptions matter. You, as a parent, may be completely committed to treating your male and female children equally. But no sane parents would treat a fearful child the same way they treat an angry child. If knowledge of a child's gender affects adults' perception of that child, then male and female children are going to elicit different reactions from the world, different patterns of encouragement. These perceptions matter, even in parents who are committed to treating sons and daughters alike.

I will give you one last version of a gender-labeling study. This one hits particularly close to home. The subjects in the study were people like Steve and me: professors of psychology, who were sent some vitas to evaluate as applicants for a tenure track position. Two different vitas were used in the study. One was a vita of a walk-on-water candidate, best candidate you've ever seen, you would die to have this person on your faculty. The other vita was a middling, average vita among successful candidates. For half the professors, the name on the vita was male, for the other half the name was female. People were asked a series of questions: What do you think about this candidate's research productivity? What do you think about his or her teaching experience? And finally, Would you hire this candidate at your university?

For the walk-on-water candidate, there was no effect of gender labeling on these judgments. I think this finding supports Steve's view that we're dealing with little overt discrimination at universities. It's not as if professors see a female name on a vita and think, I don't want her. When the vita's great, everybody says great, let's hire.

What about the average successful vita, though: that is to say, the kind of vita that professors most often must evaluate? In that case, there were differences. The male was rated as having higher research productivity. These psychologists, Steve's and my colleagues, looked at the same number of publications and thought, "good productivity" when the name was male, and "less good productivity" when the name was female. Same thing for teaching experience. The very same list of courses was seen as good teaching experience when the name was male, and less good teaching experience when the name was female. In answer to the question would they hire the candidate, 70% said yes for the male, 45% for the female. If the decision were made by majority rule, the male would get hired and the female would not.

A couple other interesting things came out of this study. The effects were every bit as strong among the female respondents as among the male respondents. Men are not the culprits here. There were effects at the tenure level as well. At the tenure level, professors evaluated a very strong candidate, and almost everyone said this looked like a good case for tenure. But people were invited to express their reservations, and they came up with some very reasonable doubts. For example, "This person looks very strong, but before I agree to give her tenure I would need to know, was this her own work or the work of her adviser?" Now that's a perfectly reasonable question to ask. But what ought to give us pause is that those kinds of reservations were expressed four times more often when the name was female than when the name was male.

So there's a pervasive difference in perceptions, and I think the difference matters. Scientists' perception of the quality of a candidate will influence the likelihood that the candidate will get a fellowship, a job, resources, or a promotion. A pattern of biased evaluation therefore will occur even in people who are absolutely committed to gender equity.

I have little doubt that all my colleagues here at Harvard are committed to the principle that a male candidate and a female candidate of equal qualifications should have equal chance at a job. But we also think that when we compare a more productive scholar to a less productive one, a more experienced teacher to a less experienced one, a more independent investigator to a less independent one, those factors matter as well. These studies say that knowledge of a person's gender will influence our assessment of those factors, and that's going to produce a pattern of discrimination, even in people with the best intentions.

From the moment of birth to the moment of tenure, throughout this great developmental progression, there are unintentional but pervasive and important differences in the ways that males and females are perceived and evaluated.

I have to emphasize that perceptions are not everything. When cases are unambiguous, you don't see these effects. What's more, cognitive development is robust: boys and girls show equal capacities and achievements in educational settings, including in science and mathematics, despite the very different ways in which boys and girls are perceived and evaluated. I think it's really great news that males and females develop along common paths and gain common sets of abilities. The equal performance of males and females, despite their unequal treatment, strongly suggests that mathematical and scientific reasoning has a biological foundation, and this foundation is shared by males and females.

Finally, you do not create someone who feels like a girl or boy simply by perceiving them as male or female. That's the lesson that comes from the studies of people of one sex who are raised as the opposite sex. Biological sex differences are real and important. Sex is not a cultural construction that's imposed on people.

But the question on the table is not, Are there biological sex differences? The question is, Why are there fewer women mathematicians and scientists? The patterns of bias that I described provide four interconnected answers to that question. First, and most obviously, biased perceptions produce discrimination: When a group of equally qualified men and women are evaluated for jobs, more of the men will get those jobs if they are perceived to be more qualified. Second, if people are rational, more men than women will put themselves forward into the academic competition, because men will see that they've got a better chance for success. Academic jobs will be more attractive to men because they face better odds, will get more resources, and so forth.

Third, biased perceptions earlier in life may well deter some female students from even attempting a career in science or mathematics. If your parents feel that you don't have as much natural talent as someone else whose objective abilities are no better than yours, that may discourage you, as Eccles's work shows. Finally, there's likely to be a snowball effect. All of us have an easier time imagining ourselves in careers where there are other people like us. If the first three effects perpetuate a situation where there are few female scientists and mathematicians, young girls will be less likely to see math and science as a possible life.

So by my personal scorecard, these are the major factors. Let me end, though, by asking, could Steve also be partly right? Could biological differences in motives — motivational patterns that evolved in the Pleistocene but that apply to us today — propel more men than women towards careers in mathematics and science?

My feeling is that where we stand now, we cannot evaluate this claim. It may be true, but as long as the forces of discrimination and biased perceptions affect people so pervasively, we'll never know. I think the only way we can find out is to do one more experiment. We should allow all of the evidence that men and women have equal cognitive capacity, to permeate through society. We should allow people to evaluate children in relation to their actual capacities, rather than one's sense of what their capacities ought to be, given their gender. Then we can see, as those boys and girls grow up, whether different inner voices pull them in different directions. I don't know what the findings of that experiment will be. But I do hope that some future generation of children gets to find out.

Steven Pinker & Elizabeth Spelke: Concluding Discussion

PINKER: Thanks, Liz, for a very stimulating and apposite presentation. A number of comments.
I don't dispute a lot of the points you made, but many have lost sight of the datum that we're here to explain in the first place. Basic abilities like knowing that an object is still there when you put a hankie over it, or knowing that one object can't pass through another, are not the kinds of things that distinguish someone who's capable of being a professor of physics or math from someone who isn't. And in many of the cases in which you correctly said that there is no gender difference in kids, there is no gender difference in adults either — such as the give-a-number task and other core abilities.

Also, a big concern with all of the null effects that you mentioned is statistical power. Bob Rosenthal 20 years ago pointed out that the vast majority of studies that psychologists do are incapable of detecting the kinds of results they seek, which is why it's so important to have meta-analyses and large sample sizes. I question whether all of the null results that you mentioned can really be justified, and whether they are comparable to the studies done on older kids and adults.

One place where I really do disagree with you is in the value of the SAT-M, where the "circle" has amply been broken. This is what people at the College Board are obsessed with. What you are treating as the gold standard is performance in college courses. But the datum we are disputing is not how well boys and girls do in school, or how well men and women do in college, because there we agree there is no male advantage. The phenomenon we really are discussing is performance at the upper levels: getting tenure-track job, getting patents, and so on. And here the analyses have shown that the SAT is not biased against girls. That is, a given increment in SAT score predicts a given increment in the variable of interest to the same extent whether you're male or female.

I think there may be a slight difference in which finding each of us is alluding to in talking about differences in grades. I was not suggesting that girls' better grades come about because they take easier courses; they really do get better grades holding courses constant. Rather it's the slight underprediction of grades by the SAT that can be explained in part by class choice and in part by conscientiousness.

SPELKE: Well the most recent thing that I've read about this issue is the Gallagher and Kaufman book, Gender Differences in Mathematics, which just came out about a month ago. They report that equating for classes and institutions, and looking just at A students, there's a 21 point SAT math differential; that is to say, for two students getting the same grade of A, the average for the girls on the SAT will have been 21 points lower. That differential is there at every grade level and in all the courses.

The SAT people have discussed it as a problem. One of the discussions reached the conclusion that the SAT is still useful, because although it under-predicts girls' performance in college, girls' grades over-predict their performance in college, and if you use the two together you are okay. In fact, they advised that people never take account of the SAT simply by itself, but consider it in relation to grades. When you spoke earlier about the use of GREs in admitting people to grad school, that's in fact what graduate programs do: We consider both grades and GREs.

Interestingly, though, in all of the public discussion of the relative advantages of men versus women for math and science, over the last two months, people have not used the SAT in conjunction with grades. When talking about relative ability, they've used the SAT by itself. I think that has led to a distorted conversation about this issue.

PINKER: It nonetheless remains true that in the most recent study by Lubinski and Benbow, which showed a fantastic degree of predictive power of the SAT given in 7th grade, there was no difference in predictive power in boys and girls in any of these measures.

But let me return to the datum that is at issue here, namely the differential representation of the sexes in physical sciences, mechanical engineering, and mathematics. The fact that men and women are equal overall in spatial abilities, and overall in mathematical abilities, is irrelevant to this. It may be that the particular subtalents in which women excel make them more likely to go into accounting. But the datum we are discussing is not a gender difference in accounting. The datum we are discussing is a gender difference in the physical sciences, engineering, and mathematics. And I suspect that when you look at a range of professions, the size of the sex discrepancy correlates with how much spatial manipulation (not just any kind of spatial cognition) and how much mathematical reasoning (not just any kind of mathematical ability) each of those jobs requires.

What about parents' expectations? In the 1970s the model for development was, "as the twig is bent, so grows the branch." — that subtle differences in parents' perceptions early in life can have a lasting effect. You nudge the child in a particular direction and you'll see an effect on his trajectory years later. But there is now an enormous amount of research spearheaded by the behavioral genetics revolution suggesting that that is not true. There may be effects of parental expectations and parental treatment on young children while they're still in the home, but most follow-up studies show that short of outright abuse and neglect, these effects peter out by late adolescence. And studies of adoption and of twins and other sibs reared apart suggest that any effects of the kinds of parenting that are specific to a child simply reflect the preexisting genetic traits of the child, and the additional effect of parenting peters out to nothing.

SPELKE: Can I respond to that? I think one thing is different about the gender case, compared to the early socialization effects for other kinds of categories, different styles of parenting, and so forth. The gender differences that we see reflected in parents' differing perceptions are mirrored by differing perceptions that males and females experience throughout their lives. It's not the case that idiosyncratic pairs of parents treat their kids one way, but then as soon as the children leave that environment, other people treat them differently. Rather, what we have in the case of gender is a pervasive pattern that just keeps getting perpetuated in different people. I'm rather a nativist about cognition, and I am tempted to look at that pattern and wonder, did Darwin give us some innately wrong idea about the genders? Professionals in professional contexts show the same patterns of evaluation that parents show in home contexts, and children face those patterns of evaluation, not just when they're young and at home, but continuing through high school, college, and finally with their colleagues on academic faculties. We're dealing here with a much more pervasive effect than the effects of socialization in the other studies that you've written and talked about.

PINKER: Regarding bias: as I mentioned at the outset, I don't doubt that bias exists. But the idea that the bias started out from some arbitrary coin flip at the dawn of time and that gender differences have been perpetuated ever since by the existence of that bias is extremely unlikely. In so many cases, as Eagly and the Stereotype-Accuracy people point out, the biases are accurate. Also, there's an irony in these discussion of bias. When we test people in the cognitive psychology lab, and we don't call these base rates "gender," we applaud people when they apply them. If people apply the statistics of a group to an individual case, we call it rational Bayesian reasoning, and congratulate ourselves for getting them to overcome the cognitive illusion of base rate neglect. But when people do the same thing in the case of gender, we treat Bayesian reasoning as a cognitive flaw and base-rate neglect as rational! Now I agree that applying base rates for gender in evaluating individual men and women is a moral flaw; I don't think that base rates ought to be applied in judging individuals in most cases of public decision-making. But the fact that the statistics of a gender are applied does not mean that their origin was arbitrary; it could be statistically sound in some cases.

SPELKE: Let me reply to that, because I agree that the origin is not arbitrary, and that the bias is there for an objective reason, but I think you're drawing the wrong conclusion about it. I think the reason there's a bias to think that men have greater natural talent for math and science is that when we look around the world and ask, who's winning the Nobel Prizes and making the great advances in science, what we see, again and again, is men.

Although Linda Buck received this year's Nobel Prize in physiology or medicine, for the most part it's overwhelmingly men who are reaching the upper levels of math and science. It's natural to look at that and think, there must be some reason, some inner difference between men and women, which produces this enormous disparity. And I quite agree with you that good statistical reasoning should lead you to think, the next student who comes along, if male, is more likely to join that group of Nobel Prize winners.

What I would like to suggest is that we have good reasons to resist this kind of conclusion, and the reasons aren't only moral. Let me just use an analogy, and replay this debate over the biological bases of mathematics and science talent 150 years ago.

Let's consider who the 19th century mathematicians and scientists were. They were overwhelmingly male, just as they are today, but also overwhelmingly European, not Asian. You won't see a Chinese face or an Indian face in 19th century science. It would have been tempting to apply this same pattern of statistical reasoning and say, there must be something about European genes that give rise to greater mathematical talent than Asian genes do. If we go back still further, and play this debate in the Renaissance, I think we would be tempted to conclude that Catholic genes make for better science than Jewish genes, because all those Renaissance scientists were Catholic. If you look at those cases, you see what's wrong with this argument.

What's wrong with the argument is not that biology is irrelevant. If Galileo had been switched at birth with some baby from the Pisan ghetto, the baby raised by Galileo's parents would not likely have ended up teaching us that the language of physics is mathematics. I think that Galileo's genes had something to do with his achievement, but so did Galileo's cultural and social environment: his nurturing. Genius requires huge amounts of both. If, in that baby switch, Galileo had found himself growing up in the Pisan ghetto, I bet he wouldn't have ended up being the example in this discussion today either. So yes, there are reasons for this statistical bias. But I think we want to step back and ask, why is it that almost all Nobel Prize winners are men today? The answer to that question may be the same reason why all the great scientists in Florence were Christian.

PINKER: I think you could take the same phenomenon and come to the opposite conclusion! Say there were really was such a self-reinforcing, self-perpetuating dynamic: a difference originates for reasons that might be arbitrary; people perceive the difference; they perpetuate it by their expectations. Just as bad, you say, is the fact that people don't go into fields in which they don't find enough people like themselves. If so, the dynamic you would expect is that the representation of different genders or ethnic groups should migrate to the extremes. That is, there is a positive feedback loop where if you're in the minority, it will discourage people like you from entering the field, which will mean that there'll be even fewer people in the field, and so on. On either side of this threshold you should get a drift of the percentages in opposite directions.

Now, there is an alternative model. At many points in history, arbitrary barriers against the entry of genders and races and ethnic groups to various professions were removed. And as soon as the barrier was removed, far from the statistical underrepresentation perpetuating or exaggerating itself, as you predict, the floodgates open, and the formerly underrepresented people reaches some natural level. It's the Jackie Robinson effect in baseball. In the case of gender and science, remember what our datum is. It's not that women are under-represented in professions in general or in the sciences in general: in many professions women are perfectly well represented, such as being a veterinarian, in which the majority of recent graduates are women by a long shot. If you go back fifty years or a hundred years, there would have been virtually no veterinarians who were women. That underrepresentation did not perpetuate itself via the positive feedback loop that you allude to.

SPELKE: I'm glad you brought up the case of the basketball and baseball players. I think it's interesting to ask, what distinguishes these cases, where you remove the overt discrimination and within a very short period of time the differential disappears, from other cases, where you remove the overt discrimination and the covert discrimination continues? In the athletic cases where discrimination disappears quickly, there are clear, objective measures of success. Whatever people think about the capacities of a black player, if he is hitting the ball out of the park, he is going to get credit for a home run. That is not the case in science.

In science, the judgments are subjective, every step of the way. Who's really talented? Who deserves bigger lab space? Who should get the next fellowship? Who should get promoted to tenure? These decisions are not based on clear and objective criteria. These are the cases where you see discrimination persisting. You see it in academia. You see it in Claudia Goldin's studies of orchestra auditions, which also involve subtle judgments: Who's the more emotive, sensitive player? If you know that the players are male or female, you're going pick mostly men, but if the players are behind a screen, you'll start picking more women.

PINKER: But that makes the wrong prediction: the harder the science, the greater the participation of women! We find exactly the opposite: it's the most subjective fields within academia — the social sciences, the humanities, the helping professions — that have the greatest representation of women. This follows exactly from the choices that women express in what gives them satisfaction in life. But it goes in the opposite direction to the prediction you made about the role of objective criteria in bringing about gender equity. Surely it's physics, and not, say, sociology, that has the more objective criteria for success.

SPELKE: Let me just say one thing, because I didn't say much in the talk at all, about this issue of motives, and biological differences in motives. That's been a less controversial issue, but I think it's an important one, and most of your examples were concerned with it. I think it's a really interesting possibility that the forces that were active in our evolutionary past have led men and women to evolve somewhat differing concerns. But to jump from that possibility into the present, and draw conclusions about what people's motives will be for pursuing one or another career, is way too big a stretch.

As we both agree, the kinds of careers people pursue now, the kinds of choices they make, are radically different from anything that anybody faced back in the Pleistocene. It is anything but clear how motives that evolved then translate into a modern context. Let me just give one example of this. You've suggested, as a hypothesis, that because of sexual selection and also parental investment issues, men are selected to be more competitive, and women are selected to be more nurturant. Suppose that hypothesis is true. If we want to use it to make predictions about desires for careers in math and science, we're going to have to answer a question that I think is wide open right now. What makes for better motives in a scientist?

What kind of motives are more likely to lead to good science: Competitive motives, like the motive J. D. Watson described in The Double Helix, to get the structure of DNA before Linus Pauling did? Or nurturant motives of the kind that Doug Melton has described recently to explain why he's going into stem cell research: to find a cure for juvenile diabetes, which his children suffer from? I think it's anything but clear how motives from our past translate into modern contexts. We would need to do the experiment, getting rid of discrimination and social pressures, in order to find out.